Hammond J B, Offen W W
Gastroenterology Section, Veterans Administration Medical Center North Chicago, Illinois.
Am J Gastroenterol. 1988 Jan;83(1):32-6.
The effect of nizatidine, a new histamine H2 receptor antagonist, on gastric secretory function of eight normal subjects stimulated with betazole, was compared with that of cimetidine. Single oral doses of 75 mg, 150 mg, and 300 mg nizatidine, 300 mg cimetidine, and a placebo were administered on separate occasions 1 h before betazole stimulation. Gastric secretions were recovered in 15-min fractions for the ensuing 2 h, and the pH, H+ concentration and output, volume, and pepsin concentration and output were determined. Doses of 150 mg and 300 mg nizatidine depressed the secretory response significantly more than did cimetidine. The antisecretory effects of 75 mg nizatidine was no different than that of 300 mg cimetidine. Nizatidine 300 mg inhibited pepsin output significantly more than volume. Although pepsin concentration was reduced more than volume, the difference was not significant. These observations, in contrast to results of previous studies, suggest a direct inhibition of pepsin secretion, although to a lesser extent than that of acid.
将新型组胺H2受体拮抗剂尼扎替丁对8名用倍他唑刺激的正常受试者胃分泌功能的影响与西咪替丁进行了比较。在倍他唑刺激前1小时，分别单次口服75毫克、150毫克和300毫克尼扎替丁、300毫克西咪替丁和安慰剂。在随后的2小时内，以15分钟的间隔收集胃分泌物，并测定pH值、氢离子浓度和输出量、体积以及胃蛋白酶浓度和输出量。150毫克和300毫克剂量的尼扎替丁比西咪替丁更显著地抑制分泌反应。75毫克尼扎替丁的抗分泌作用与300毫克西咪替丁的无差异。300毫克尼扎替丁对胃蛋白酶输出的抑制明显大于对体积的抑制。虽然胃蛋白酶浓度的降低幅度大于体积，但差异不显著。与先前研究结果相反，这些观察结果表明尼扎替丁对胃蛋白酶分泌有直接抑制作用，尽管程度小于对胃酸的抑制。
