Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, #38 Xueyuan Road, Beijing 100191, China.
Int J Biol Sci. 2017 Jul 18;13(8):1008-1018. doi: 10.7150/ijbs.19891. eCollection 2017.
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In this review, we briefly introduce the current knowledge of the linker histone, including its structure, characteristics and functions. Also, we move forward to present the advances of the linker histone's association with certain diseases, such as cancer, Alzheimer's disease, infection, male infertility and aberrant immunity situations, focusing on the alteration of the linker histone under certain pathological conditions and its role in developing each disease.
连接组蛋白是一种与核小体结合的蛋白质，通常被认为可以实现核内染色质的浓缩。越来越多的证据表明，连接组蛋白在几种疾病的发病机制中是必不可少的。在这篇综述中，我们简要介绍了连接组蛋白的现有知识，包括其结构、特征和功能。此外，我们还介绍了连接组蛋白与某些疾病的关联的最新进展，如癌症、阿尔茨海默病、感染、男性不育和异常免疫情况，重点介绍了在某些病理条件下连接组蛋白的变化及其在每种疾病发展中的作用。
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