早熟女孩及其母亲的一年随访：心理评估是否随时间或治疗而变化？
One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment?
机构信息
Pediatrics, Section of Pediatric Endocrinology, Riley Hospital for Children, Indianapolis, Indiana, USA.
Pediatrics, Section of Adolescent Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
Horm Res Paediatr. 2017;88(5):347-353. doi: 10.1159/000479688. Epub 2017 Sep 19.
BACKGROUND
To determine whether psychological characteristics of girls with variations of early puberty and their mothers change over time and with treatment in girls with central precocious puberty (CPP).
METHODS
Girls with CPP, premature adrenarche (PA), and early normal puberty (ENP) completed psychological assessments at baseline and after 1 year along with their mothers. All girls with CPP were treated with GnRH analogs. Psychological effects of group and time were examined using 2 × 3 mixed ANOVAs.
RESULTS
Sixty-two subjects aged 7.5 ± 1.4 years (range 4.8-10.5) were enrolled, of whom 36 (15 with CPP, 8 with PA, and 13 with ENP) completed 1-year follow-up assessments. Psychological measures were normal in all girls. No significant group differences were found for any measure of girls' psychological functioning at either time point. However, across all groups there was change over time with a decrease in perceived physical competence (p < 0.001) and an increase in perceived maternal acceptance (p = 0.001).
CONCLUSION
No abnormalities in psychological functioning were found among girls with variations of early puberty, and all groups were in the normal range. Our results are largely reassuring regarding concerns of adverse psychological consequences of early puberty in girls.
背景
为了确定中枢性性早熟（CPP）女孩及其母亲的心理特征是否随时间和治疗而变化，我们研究了青春期提前和早期正常青春期的女孩。
方法
CPP、过早性发育（PA）和早期正常青春期（ENP）的女孩在基线和 1 年后与她们的母亲一起完成心理评估。所有 CPP 女孩均接受 GnRH 类似物治疗。使用 2×3 混合方差分析检查组间和时间的心理影响。
结果
共纳入 62 名年龄为 7.5±1.4 岁（范围为 4.8-10.5）的受试者，其中 36 名（15 名 CPP、8 名 PA 和 13 名 ENP）完成了 1 年的随访评估。所有女孩的心理测量均正常。在任何时间点，女孩心理功能的任何测量指标均未显示出组间差异。然而，所有组在时间上均有变化，表现为感知身体能力下降（p<0.001）和感知母亲接受度增加（p=0.001）。
结论
青春期提前的女孩在心理功能方面未发现异常，所有组均处于正常范围。我们的结果在很大程度上消除了对青春期早期对女孩产生不良心理后果的担忧。
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