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耳鸣的遗传学:是时候建立幻听生物样本库了。

Genetics of Tinnitus: Time to Biobank Phantom Sounds.

作者信息

Cederroth Christopher R, Kähler Anna K, Sullivan Patrick F, Lopez-Escamez Jose A

机构信息

Experimental Audiology, Department of Physiology and Pharmacology, Karolinska InstitutetStockholm, Sweden.

Department of Molecular Epidemiology and Biostatistics, Karolinska InstitutetStockholm, Sweden.

出版信息

Front Genet. 2017 Sep 4;8:110. doi: 10.3389/fgene.2017.00110. eCollection 2017.

Abstract

Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists. While the existing evidence for a genetic influence on the condition has been until now sparse and underpowered, recent data suggest that specific forms of tinnitus have a strong genetic component revealing that not all tinnitus percepts are alike, at least in how they are genetically driven. These new findings pave the way for a better understanding on how phantom sensations are molecularly driven and call for international biobanking efforts.

摘要

耳鸣是一种常见的幻听现象,最常由感觉剥夺引起,而目前关于其分子机制的了解甚少。虽然迄今为止,关于遗传因素对耳鸣影响的现有证据稀少且说服力不足,但最近的数据表明,特定形式的耳鸣具有很强的遗传成分,这表明并非所有耳鸣感知都是相同的,至少在遗传驱动方式上是如此。这些新发现为更好地理解幻听现象的分子驱动机制铺平了道路,并呼吁开展国际生物样本库工作。

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