Piran Siavash, Schulman Sam
Department of Medicine, Division of Hematology and Thromboembolism and Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada.
Case Rep Hematol. 2017;2017:3159363. doi: 10.1155/2017/3159363. Epub 2017 Aug 27.
We present a case of renal infarction in a 43-year-old female with history of stroke at age 14. She was found to be heterozygous for the prothrombin G20210A gene mutation. Loop monitoring revealed no atrial fibrillation. Transthoracic and transesophageal echocardiograms showed no thrombus. However, there was a small shunt due to an atrial septal defect (ASD). She was treated with warfarin and had device closure of her ASD. This was a suspected case of paradoxical embolism through an ASD leading to renal infarction.
我们报告一例43岁女性肾梗死病例，该女性14岁时有中风病史。她被发现凝血酶原G20210A基因突变呈杂合状态。动态心电图监测未发现房颤。经胸和经食管超声心动图均未显示血栓。然而，因房间隔缺损（ASD）存在小分流。她接受了华法林治疗，并对房间隔缺损进行了封堵术。这是一例疑似通过房间隔缺损发生反常栓塞导致肾梗死的病例。
