Pérez-Ramírez Cristina, Alnatsha Ahmed, Cañadas-Garre Marisa, Villar Eduardo, Valdivia-Bautista Javier, Faus-Dáder María J, Calleja-Hernández Miguel Á
aPharmacogenetics Unit, Pharmacy Service bPathology Service, UGC Pathological Anatomy cMedical Oncology Service, Biosanitary Research Institute, University Hospital Complex of Granada Departments of dBiochemistry ePharmacology, Faculty of Pharmacy, University of Granada, Granada, Spain fDepartment of Molecular Medicine, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
Pharmacogenet Genomics. 2017 Dec;27(12):438-444. doi: 10.1097/FPC.0000000000000307.
Lung cancer, particularly the non-small-cell lung cancer (NSCLC) subtype, is the leading cause of cancer-related death worldwide. Several functional polymorphisms in inflammatory cytokine genes, such as IL1B, IL6, IL12A, IL13 and IL16, have been associated with the risk of NSCLC. The aim of this study was to evaluate the association between ILs gene polymorphisms and the risk of developing NSCLC.
A retrospective case-control study was carried out, including 174 NSCLC cases and 298 controls of Spanish origin. IL1B (rs1143634), IL1B (rs12621220), IL1B (rs1143623), IL1B (rs16944), IL1B (rs1143627), IL12A (rs662959), IL13 (rs1881457), IL6 (rs1800795) and IL16 (rs7170924) gene polymorphisms were analysed by TaqMan.
The genotypic logistic regression model adjusted by smoking status showed that the IL1B rs1143634-TT genotype was associated with a lower risk of NSCLC (P=0.04312; odds ratio=0.226; 95% confidence interval=0.044-0.840). No other gene polymorphisms showed an association with NSCLC in any of the models tested.
In conclusion, IL1B rs1143634 was significantly associated with a higher risk of NSCLC. No influence of IL1B rs12621220, rs1143623, rs16944, rs1143627, IL12A rs662959, IL13 rs1881457 and IL16 rs7170924 on the risk of developing NSCLC was found in our study.
肺癌，尤其是非小细胞肺癌（NSCLC）亚型，是全球癌症相关死亡的主要原因。炎症细胞因子基因中的几种功能多态性，如IL1B、IL6、IL12A、IL13和IL16，已与NSCLC的风险相关。本研究的目的是评估白细胞介素（ILs）基因多态性与发生NSCLC风险之间的关联。
开展了一项回顾性病例对照研究，包括174例NSCLC病例和298例西班牙裔对照。通过TaqMan分析IL1B（rs1143634）、IL1B（rs12621220）、IL1B（rs1143623）、IL1B（rs16944）、IL1B（rs1143627）、IL12A（rs662959）、IL13（rs1881457）、IL6（rs1800795）和IL16（rs7170924）基因多态性。
经吸烟状况调整的基因型逻辑回归模型显示，IL1B rs1143634 - TT基因型与较低的NSCLC风险相关（P = 0.04312；优势比 = 0.226；95%置信区间 = 0.044 - 0.840）。在任何测试模型中，其他基因多态性均未显示与NSCLC有关联。
总之，IL1B rs1143634与较高的NSCLC风险显著相关。在我们的研究中，未发现IL1B rs12621220、rs1143623、rs16944、rs1143627、IL12A rs662959、IL13 rs1881457和IL16 rs7170924对发生NSCLC风险有影响。
Zotero 插件