脂质自由基会导致光诱导的视网膜变性。
Lipid radicals cause light-induced retinal degeneration.
作者信息
Enoki Masataka, Shinto Saki, Matsuoka Yuta, Otsuka Ayasa, Kaidzu Sachiko, Tanito Masaki, Shibata Takahiro, Uchida Koji, Ohira Akihiro, Yamato Mayumi, Yamada Ken-Ichi
机构信息
Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.
出版信息
Chem Commun (Camb). 2017 Oct 3;53(79):10922-10925. doi: 10.1039/c7cc03387g.
Age-related macular degeneration (AMD) is the leading cause of blindness worldwide. Although the cause of AMD remains unknown, lipid peroxidation (LPO) end-products are critical molecules for its development. Herein, we report the imaging of lipid radicals, which are key factors in the LPO reaction, and therapeutic information using animal models.
年龄相关性黄斑变性（AMD）是全球失明的主要原因。尽管AMD的病因尚不清楚，但脂质过氧化（LPO）终产物是其发展的关键分子。在此，我们报告了脂质自由基的成像以及使用动物模型的治疗信息，脂质自由基是LPO反应中的关键因素。
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