2型糖尿病中二甲双胍诱导的维生素B12缺乏所致周围神经病变的研究进展
Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM.
作者信息
Ahmed Marwan A, Muntingh George L, Rheeder Paul
机构信息
Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Department of Internal Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
出版信息
Int J Endocrinol. 2017;2017:2452853. doi: 10.1155/2017/2452853. Epub 2017 Aug 27.
Abstract
Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.
摘要
周围神经病变（PN）是2型糖尿病（T2DM）的主要并发症，也是维生素B12缺乏的直接表现。在临床研究显示二甲双胍具有降低维生素B12的作用后，研究二甲双胍对PN状态的影响变得势在必行。该主题的复杂性以及结果的不一致性，需要从特定主题的角度进行考量，以便更好地理解现有证据并更合理地设计未来研究。
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