芳氧基乙炔基硅烷的邻位 C-H 活化的分子内反芳构化氢酰化合成苯并硅杂环。
Synthesis of Benzosiloles by Intramolecular anti-Hydroarylation via ortho-C-H Activation of Aryloxyethynyl Silanes.
机构信息
Research and Development Initiative, Chuo University , 1-13-27, Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
Department of Applied Chemistry, Chuo University , 1-13-27, Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
出版信息
J Am Chem Soc. 2017 Oct 11;139(40):14013-14016. doi: 10.1021/jacs.7b08055. Epub 2017 Sep 26.
PMID:28933842
Abstract
Straightforward synthesis of benzosiloles was achieved by the invention of Pd/acid-catalyzed intramolecular anti-hydroarylation of aryloxyethynyl(aryl)silanes via ortho-C-H bond activation. The aryloxy group bound to the ethynyl carbon is the key factor for this transformation.
摘要
本发明通过 Pd/酸催化的芳氧基乙炔基（芳基）硅烷的分子内反芳构化反应，实现了苯并硅咯的简便合成，通过邻-C-H 键活化。与乙炔基碳相连的芳氧基是这种转化的关键因素。
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