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关于骨髓增殖综合征患者中骨髓增殖因子的存在(作者译)

[On the existence of a myeloproliferative factor in patients with a myeloproliferative syndrome (author's transl)].

作者信息

Essers U, Nowak H

出版信息

Blut. 1979 Aug;39(2):107-15. doi: 10.1007/BF01008086.

Abstract

Serum of patients suffering from a chronic myeloproliferative disorder (polycythaemia, era, osteomyelofibrosis, chronic myeloid leukaemia) and serum of lethally irradiated rats injected before application of a single doses of erythropoietin did not enhance the effect of erythropoietin -- measured with the iron incorporation rate of polycythemic mice. The rationale for these experiments is to try to find a "myeloproliferative factor", which augments the number of stem cells as described in sera of patients with polycythaemia vera, osteomyelofibrosis, and lethally irradiated mice.

摘要

患有慢性骨髓增殖性疾病(真性红细胞增多症、原发性骨髓纤维化、骨髓纤维化、慢性粒细胞白血病)的患者血清,以及在单次注射促红细胞生成素之前接受致死剂量照射的大鼠血清,均未增强促红细胞生成素的效果——这是通过真性红细胞增多症小鼠的铁掺入率来衡量的。这些实验的基本原理是试图找到一种“骨髓增殖因子”,这种因子能像真性红细胞增多症、骨髓纤维化患者血清以及接受致死剂量照射的小鼠血清中所描述的那样增加干细胞数量。

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