Health Center 4 Consulting Room for Parkinson's Disease and Other Movement Disorders Riga Latvia.
Medical Faculty of University of Latvia Riga Latvia.
Brain Behav. 2017 Aug 2;7(9):e00781. doi: 10.1002/brb3.781. eCollection 2017 Sep.
Essential tremor (ET) and Parkinson's disease (PD) are the two most common movement disorders, and tremor is the most visible symptom. Comparative study on ET and PD clinical neuropsychiatric symptoms was performed to assess the impact of emotional state on tremor.
To investigate the most common psychiatric symptoms (depression, anxiety and social phobia) and their correlations with motor symptoms, especially tremor, in ET and PD patients.
This comparative cross-sectional study consisted of neurological examinations, five self-assessment questionnaires (Depression Anxiety Stress Scale [DASS], Beck Depression Inventory [BDI], Social Interaction Anxiety Scale [SIAS], Social Phobia Scale [SPS], and State-Trait Anxiety Inventory[STAI]), clinical interviews with 45 ET patients, 40 PD patients, and 40 controls (CG), and statistical analysis was performed for 40:35:39 respectively.
BDI revealed depressive disorders of various severities in all groups (ET=79.5%, PD=91.2%, and CG=66.7%). The study found no significant difference between ET and PD groups ( = .708) and significant difference between the patients and controls (ET/CG = .049; PD/CG = .007). Depression (DASS(D), BDI) did not correlate with tremor severity ( > .05) in ET and PD patients. The prevalence of social phobia was ET=50.0%, PD=42.9%, and CG=20.5%. There was significant difference between ET/CG (SIAS = .02, SPS = .001) and PD/CG (SPS = .018), but no difference between ET and PD groups ( > .05). Tremor and SPS moderately correlated in ET patients ( = .35, = .02).
ET and PD patients showed high comorbidity of psychiatric disorders, but there was no significant difference between these two groups. ET severity correlated with social phobia scale scores.
特发性震颤（ET）和帕金森病（PD）是两种最常见的运动障碍，震颤是最明显的症状。对 ET 和 PD 临床神经精神症状进行了比较研究，以评估情绪状态对震颤的影响。
探讨 ET 和 PD 患者中最常见的精神科症状（抑郁、焦虑和社交恐惧症）及其与运动症状，尤其是震颤的相关性。
这项横断面比较研究包括神经系统检查、五个自我评估问卷（抑郁焦虑压力量表[DASS]、贝克抑郁量表[BDI]、社交互动焦虑量表[SIAS]、社交恐惧症量表[SPS]和状态特质焦虑量表[STAI]）、对 45 名 ET 患者、40 名 PD 患者和 40 名对照组（CG）进行临床访谈，并分别对 40：35：39 进行了统计分析。
BDI 显示所有组均存在不同严重程度的抑郁障碍（ET=79.5%、PD=91.2%和 CG=66.7%）。研究发现 ET 和 PD 组之间无显著差异（=.708），但患者与对照组之间存在显著差异（ET/CG = .049；PD/CG = .007）。ET 和 PD 患者的抑郁（DASS(D)、BDI）与震颤严重程度无关（>.05）。社交恐惧症的患病率为 ET=50.0%、PD=42.9%和 CG=20.5%。ET/CG 之间存在显著差异（SIAS = .02、SPS = .001）和 PD/CG（SPS = .018），但 ET 和 PD 组之间无差异（>.05）。ET 患者的震颤与 SPS 中度相关（=.35、=.02）。
ET 和 PD 患者存在较高的精神障碍共病，但两组之间无显著差异。ET 严重程度与社交恐惧症量表评分相关。
