Val158Met 多态性对胼胝体结构的性别特异性影响：全脑弥散加权成像研究。
Sex-specific effects of Val158Met polymorphism on corpus callosum structure: A whole-brain diffusion-weighted imaging study.
机构信息
Université François-Rabelais de ToursInserm UMR U930 'Imagerie et Cerveau' Tours France.
Clinique Psychiatrique Universitaire CHRU de Tours Tours France.
出版信息
Brain Behav. 2017 Aug 9;7(9):e00786. doi: 10.1002/brb3.786. eCollection 2017 Sep.
BACKGROUND
Genetic polymorphisms play a significant role in determining brain morphology, including white matter structure and may thus influence the development of brain functions. The main objective of this study was to examine the effect of Val158Met (rs4680) polymorphism of Catechol--Methyltransferase () gene on white matter connectivity in healthy adults.
METHODS
We used a whole-brain diffusion-weighted imaging method with Tract-Based Spatial Statistics (TBSS) analysis to examine white matter structural integrity in intrinsic brain networks on a sample of healthy subjects ( = 82).
RESULTS
Results revealed a sex-specific effect of on corpus callosum (CC): in males only, homozygotes had significantly higher fractional anisotropy (FA) compared to -carriers. Volume-of-interest analysis showed a genotype by sex interaction on FA in genu and rostral midbody of CC, whereby Val males demonstrated higher FA than Met females.
CONCLUSIONS
These results demonstrate the key effect of genes by sex interaction, rather than their individual contribution, on the corpus callosum anatomy.
背景
遗传多态性在确定大脑形态方面起着重要作用，包括白质结构，因此可能会影响大脑功能的发展。本研究的主要目的是探讨儿茶酚-O-甲基转移酶（）基因 Val158Met(rs4680)多态性对健康成年人白质连接的影响。
方法
我们使用全脑弥散加权成像方法和基于束的空间统计学（TBSS）分析，在健康受试者样本中检查内在脑网络的白质结构完整性（n=82）。
结果
结果显示，儿茶酚-O-甲基转移酶（）对胼胝体（CC）的作用存在性别特异性：仅在男性中，-纯合子的各向异性分数（FA）明显高于-携带者。感兴趣体积分析显示，CC 体部和前中部 FA 存在基因型与性别的交互作用，即 Val 男性的 FA 高于 Met 女性。
结论
这些结果表明，基因与性别的相互作用对胼胝体解剖结构有重要影响，而不是它们各自的贡献。
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