Centro Vivir con Diabetes, Av. Simón López, No. 375, Cochabamba, Bolivia.
International Diabetes Federation Life for a Child Program, Glebe, NSW 2037, Australia.
J Diabetes Res. 2017;2017:8454757. doi: 10.1155/2017/8454757. Epub 2017 Aug 29.
To determine incidence, mortality, and clinical status of youth with diabetes at the Centro Vivir con Diabetes, Cochabamba, Bolivia, with support from International Diabetes Federation Life for a Child Program.
Incidence/mortality data analysis of all cases (<25 year (y)) diagnosed January 2005-February 2017 and cross-sectional data (December 2015).
Over 12.2 years, 144 cases with type 1 diabetes (T1D) were diagnosed; 43.1% were male. Diagnosis age was 0.3-22.2 y; peak was 11-12 y. 11.1% were <5 y; 29.2%, 5-<10 y; 43.1%, 10-<15 y; 13.2%, 15-<20 y; and 3.5%, 20-<25 y. The youngest is being investigated for monogenic diabetes. Measured incidence in Cercado Province (Cochabamba Department) was 2.2/100,000 children < 15 y/y, with ≈80% ascertainment, giving total incidence of 2.7/100,000 children < 15 y/y. Two had died. Crude mortality rate was 2.3/1000 patient years. Clinical data on 141 cases <35 y: mean/median HbA1c was 8.5/8.2% (69/62 mmol/mol), levels higher in adolescents. Three were on renal replacement therapy; four others had substantial renal impairment. Elevated BMI, triglycerides, and cholesterol were common: 19.1%, 18.3%, and 39.1%, respectively.
Bolivia has low T1D incidence. Reasonable glycemic control is being achieved despite limited resources; however, some have serious complications and adverse cardiovascular risk factor profiles. Further attention is needed for complications.
在国际糖尿病联合会儿童生活项目的支持下，确定玻利维亚科恰班巴 Vivir con Diabetes 中心患有糖尿病的青年的发病率、死亡率和临床状况。
对 2005 年 1 月至 2017 年 2 月期间诊断的所有病例(<25 岁)的发病率/死亡率数据进行分析，并对 2015 年 12 月的横断面数据进行分析。
在 12.2 年期间，共诊断出 144 例 1 型糖尿病（T1D）患者；其中 43.1%为男性。诊断年龄为 0.3-22.2 岁；高峰为 11-12 岁。11.1%的患者年龄<5 岁；29.2%的患者年龄为 5-<10 岁；43.1%的患者年龄为 10-<15 岁；13.2%的患者年龄为 15-<20 岁；3.5%的患者年龄为 20-<25 岁。最年轻的患者正在接受单基因糖尿病的调查。在科恰班巴省（Cochabamba Department）的测量发病率为每 10 万名<15 岁儿童 2.2 例，检出率约为 80%，因此儿童<15 岁的总发病率为每 10 万名儿童 2.7 例。有 2 例死亡。粗死亡率为每 1000 患者年 2.3 例。对 141 例<35 岁的病例进行临床数据分析：平均/中位数糖化血红蛋白为 8.5/8.2%（69/62mmol/mol），青少年的水平较高。有 3 例正在接受肾脏替代治疗；另外 4 例有严重的肾功能损害。升高的体重指数、甘油三酯和胆固醇很常见，分别为 19.1%、18.3%和 39.1%。
玻利维亚的 T1D 发病率较低。尽管资源有限，但仍实现了合理的血糖控制；然而，一些患者存在严重的并发症和不良的心血管危险因素谱。需要进一步关注并发症。
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