表皮生长因子受体信号传导在眼睑及睑板腺形态发生中的作用。
Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands.
作者信息
Dong Fei, Call Mindy, Xia Ying, Kao Winston W-Y
机构信息
Department of Ophthalmology, College of Medicine University of Cincinnati, Cincinnati, OH, USA.
Department of Ophthalmology, College of Medicine University of Cincinnati, Cincinnati, OH, USA; Department of Environmental Health, College of Medicine University of Cincinnati, Cincinnati, OH, USA.
出版信息
Exp Eye Res. 2017 Oct;163:58-63. doi: 10.1016/j.exer.2017.04.006.
The epidermal growth factor receptor (EGFR) signaling has a pivotal role in the regulation of morphogenesis during development and maintenance of homeostasis in adult eyelid and its adnexa. Studies have demonstrated that during eyelid morphogenesis the EGFR signaling pathway is responsible for keratinocyte and mesenchymal cell proliferation and migration at the eyelid tip. For meibomian gland morphogenesis, EGFR signaling activation stimulates meibomian gland epithelial cell proliferation. EGFR signaling pathway functions through multiple downstream signals such as ERK, Rho/ROCK and integrin and is regulated by a variety of upstream signals including Adam17, GPR48 and FGFR signaling. Herein we review the literature that describe the role of EGFR and its related signaling pathways in eyelid and meibomian gland morphogenesis.
表皮生长因子受体（EGFR）信号传导在发育过程中的形态发生调节以及成年眼睑及其附属器的稳态维持中起关键作用。研究表明，在眼睑形态发生过程中，EGFR信号通路负责眼睑尖端的角质形成细胞和间充质细胞的增殖与迁移。对于睑板腺形态发生，EGFR信号激活刺激睑板腺上皮细胞增殖。EGFR信号通路通过多种下游信号如ERK、Rho/ROCK和整合素发挥作用，并受多种上游信号包括Adam17、GPR48和FGFR信号的调节。在此，我们综述描述EGFR及其相关信号通路在眼睑和睑板腺形态发生中作用的文献。
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