Dipartimento di Neuroscience, Salute Mentale e Organi di Senso, "Sapienza" Università di Roma, Via di Grottarossa, 1035, 00189, Rome, Italy.
Museo Storico della Fisica e Centro Studi e Ricerche "Enrico Fermi", Piazza del Viminale, 1, 00184, Rome, Italy.
Neurol Sci. 2018 Jan;39(1):141-143. doi: 10.1007/s10072-017-3123-2. Epub 2017 Sep 27.
Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson's disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson's disease patients.
剂末现象是指左旋多巴药效结束时出现的可预测的帕金森病运动及非运动症状恶化，在下一次服药后可改善。在此，我们研究了雷沙吉兰对出现剂末现象患者的左旋多巴药效结束时执行功能的疗效。雷沙吉兰耐受性良好，可显著改善额叶评估成套测验的评分，同时改善左旋多巴药效结束时的运动症状。这些结果表明，雷沙吉兰治疗剂末现象的运动症状可能伴随着执行功能的改善，进一步支持了优化波动型帕金森病患者多巴胺替代治疗的必要性。
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