基质金属蛋白酶基因多态性、MMP -1 -1607 1G/2G、-519 A/G以及MMP -12 -82 A/G与缺血性脑卒中：一项荟萃分析
MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis.
作者信息
Zhang Guoqian, Li Wei, Guo Yuying, Li Dan, Liu Yunde, Xu Shixin
机构信息
Department of Clinical Laboratory, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
出版信息
J Stroke Cerebrovasc Dis. 2018 Jan;27(1):140-152. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.021. Epub 2017 Sep 27.
BACKGROUND
Several polymorphisms in the human gene encoding MMP have been investigated for the association with ischemic stroke (IS) in the population, of which the MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G polymorphisms gain more and more attention; however, the results are controversial and ambiguous. We therefore carried out the meta-analysis to yield a valid conclusion.
METHODS
The literature database was comprehensively searched to identify potentially eligible reports.
RESULTS
A total of 15 studies with 3237 cases and 3075 controls were included in this meta-analysis.
CONCLUSIONS
There was a significant association in MMP-1 -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms, but none was observed in MMP-1 -519 A/G. When a subgroup analysis by ethnicity and HWE, MMP-12 -82 A/G gene polymorphisms may be a risk factor for IS in Europe. In Africa, MMP-1 -1607 1G/2G and MMP-12 -82 A/G also showed a significant effect on IS. Further investigation on a larger sample size of different ethnic populations is needed to confirm the findings.
背景
编码基质金属蛋白酶（MMP）的人类基因中的几种多态性已在人群中研究与缺血性中风（IS）的关联，其中MMP-1 -1607 1G/2G、-519 A/G以及MMP-12 -82 A/G多态性越来越受到关注；然而，结果存在争议且不明确。因此，我们进行了荟萃分析以得出有效结论。
方法
全面检索文献数据库以识别潜在符合条件的报告。
结果
本荟萃分析共纳入15项研究，包括3237例病例和3075例对照。
结论
MMP-1 -1607 1G/2G和MMP-12 -82 A/G基因多态性存在显著关联，但MMP-1 -519 A/G未观察到关联。按种族和哈迪-温伯格平衡（HWE）进行亚组分析时，MMP-12 -82 A/G基因多态性可能是欧洲IS的一个危险因素。在非洲，MMP-1 -1607 1G/2G和MMP-12 -82 A/G对IS也有显著影响。需要对更大样本量的不同种族人群进行进一步研究以证实这些发现。
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