Chen Kok-Siong, Lim Jonathan W C, Richards Linda J, Bunt Jens
Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia; The School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia.
Cancer Lett. 2017 Dec 1;410:124-138. doi: 10.1016/j.canlet.2017.09.015. Epub 2017 Sep 28.
The nuclear factor I (NFI) transcription factors play important roles during normal development and have been associated with developmental abnormalities in humans. All four family members, NFIA, NFIB, NFIC and NFIX, have a homologous DNA binding domain and function by regulating cell proliferation and differentiation via the transcriptional control of their target genes. More recently, NFI genes have also been implicated in cancer based on genomic analyses and studies of animal models in a variety of tumours across multiple organ systems. However, the association between their functions in development and in cancer is not well described. In this review, we summarise the evidence suggesting a converging role for the NFI genes in development and cancer. Our review includes all cancer types in which the NFI genes are implicated, focusing predominantly on studies demonstrating their oncogenic or tumour-suppressive potential. We conclude by presenting the challenges impeding our understanding of NFI function in cancer biology, and demonstrate how a developmental perspective may contribute towards overcoming such hurdles.
核因子I（NFI）转录因子在正常发育过程中发挥着重要作用，并且与人类发育异常有关。所有四个家族成员，即NFIA、NFIB、NFIC和NFIX，都有一个同源的DNA结合结构域，通过对其靶基因的转录控制来调节细胞增殖和分化。最近，基于基因组分析和对多个器官系统中各种肿瘤的动物模型研究，NFI基因也与癌症有关。然而，它们在发育和癌症中的功能之间的关联尚未得到充分描述。在这篇综述中，我们总结了表明NFI基因在发育和癌症中具有趋同作用的证据。我们的综述涵盖了所有涉及NFI基因的癌症类型，主要侧重于证明其致癌或肿瘤抑制潜力的研究。我们通过提出阻碍我们理解NFI在癌症生物学中功能的挑战来得出结论，并展示从发育角度如何有助于克服这些障碍。
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