W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Science. 2017 Sep 29;357(6358):1396-1399. doi: 10.1126/science.aak9691. Epub 2017 Sep 28.
The mosquito's innate immune system controls both and bacterial infections. We investigated the competitiveness of mosquitoes genetically modified to alter expression of their own anti- immune genes in a mixed-cage population with wild-type mosquitoes. We observed that genetically modified mosquitoes with increased immune activity in the midgut tissue did not have an observed fitness disadvantage and showed reduced microbial loads in both the midgut and reproductive organs. These changes result in a mating preference of genetically modified males for wild-type females, whereas wild-type males prefer genetically modified females. These changes foster the spread of the genetic modification in a mosquito cage population.
蚊子的先天免疫系统既能控制病毒感染，也能控制细菌感染。我们研究了在与野生型蚊子混合的笼养种群中，通过基因改造改变蚊子自身免疫基因表达的蚊子的竞争力。我们发现，中肠组织免疫活性增强的转基因蚊子并没有表现出明显的适应度劣势，而且在中肠和生殖器官中的微生物负荷都有所降低。这些变化导致转基因雄蚊更喜欢野生型雌蚊，而野生型雄蚊则更喜欢转基因雌蚊。这些变化促进了基因改造在蚊子笼养种群中的传播。
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