S-Rózsa K, Salánki J
Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany.
Acta Biol Hung. 1987;38(1):31-45.
In acute experiments the interaction of heavy metals (CdCl2 and HgCl2) with neurotransmitters (ACh and 5HT) was studied on the excitable membrane of the identified neurons in the central nervous system of Helix pomatia L. (Gastropoda, Mollusca). It was shown that cadmium and mercury ions exert different influence on both resting and action potentials as well as on the responsiveness of the neural membranes to ACh and 5HT. The selective blocking effect of cadmium and mercury ions can be interpreted on the basis of specificity of postsynaptic receptor structures responsible for the transmitter action and of ion-channels involved in the excitatory processes. The heavy metal effect was not uniform for the different types of neurons, suggesting that pollutants can modify various functions to a different degree. The results show that testing on nerve cell membranes can serve as a useful method and model in investigating the effect of sublethal environmental contamination, as they may cause a profound modulation on the elements of the neural circuitry responsible for the regulation of the animal's behavior.
在急性实验中，研究了重金属（氯化镉和氯化汞）与神经递质（乙酰胆碱和5-羟色胺）在罗马蜗牛（腹足纲，软体动物）中枢神经系统中已鉴定神经元的可兴奋膜上的相互作用。结果表明，镉离子和汞离子对静息电位和动作电位以及神经膜对乙酰胆碱和5-羟色胺的反应性均有不同影响。镉离子和汞离子的选择性阻断作用可根据负责递质作用的突触后受体结构的特异性以及参与兴奋过程的离子通道来解释。重金属对不同类型神经元的作用并不一致，这表明污染物可在不同程度上改变各种功能。结果表明，对神经细胞膜进行测试可作为研究亚致死性环境污染影响的一种有用方法和模型，因为它们可能对负责调节动物行为的神经回路元件产生深远调节作用。
