利用17号染色体的DNA标记对冯雷克林霍增氏神经纤维瘤病（NF1）进行连锁分析。
Linkage analysis in von Recklinghausen neurofibromatosis (NF1) with DNA markers for chromosome 17.
作者信息
Seizinger B R, Rouleau G A, Lane A H, Farmer G, Ozelius L J, Haines J L, Parry D M, Korf B R, Pericak-Vance M A, Faryniarz A G
机构信息
Neurogenetics Labortory, Massachusetts General Hospital, Boston.
出版信息
Genomics. 1987 Dec;1(4):346-8. doi: 10.1016/0888-7543(87)90035-8.
The mutant gene causing von Recklinghausen neurofibromatosis (NF1) was recently shown to map to chromosome 17. We have used additional markers for chromosome 17 to narrow further the location of the gene defect. A preliminary multipoint linkage analysis suggests that the NF1 gene is located on the long arm of chroomsome 17, flanked by D17Z1 and NGFR. Linkage analysis with the human oncogene homolog erbA1, which maps to this region, suggests that this cancer-related gene is not the primary cause of NF1.
导致冯·雷克林豪森神经纤维瘤病（NF1）的突变基因最近被证明定位于17号染色体。我们使用了更多17号染色体的标记物来进一步缩小基因缺陷的位置。初步的多点连锁分析表明，NF1基因位于17号染色体长臂上，两侧分别是D17Z1和NGFR。与定位于该区域的人类癌基因同源物erbA1进行连锁分析表明，这个与癌症相关的基因不是NF1的主要病因。
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