Patil Nilesh S, Goyal Neerav, Pareek Shishir, Nayeem Mohammed, Gupta Subhash
Centre for Liver and Biliary Surgery (CLBS), Indraprastha Apollo Hospitals, Sarita Vihar, Delhi Mathura Road, New Delhi 110076, India.
J Clin Exp Hepatol. 2017 Sep;7(3):179-183. doi: 10.1016/j.jceh.2017.05.001. Epub 2017 May 15.
To expand the donor pool, split liver transplantation is conventionally performed for one adult and one pediatric recipient. Application of this technique for two adult recipients can produce remarkable impact on the waiting list. Proper donor and recipient selection is crucial for the favorable outcome following full-right and full-left liver split. Right lobe adult to adult living donor liver transplantation (LDLT) is essentially a full right and full left split. However, LDLT techniques have not been used for full right and left split.
We performed in situ splitting of the whole liver using LDLT techniques from a hemodynamically stable young deceased donor and transplanted into two adult recipients, both with model for end-stage liver disease score of 17. The transection was carried out through the midplane of liver, generating a right lobe and a left lobe graft.
Both the recipients had uneventful postoperative recovery. At ten months of follow up, both the recipients are doing well with good liver function.
Based on the concept of living related liver transplantation, our case explores the technical feasibility of full-right and full-left in situ liver split.
为了扩大供体库,传统上劈离式肝移植是为一名成人和一名儿童受者进行的。将该技术应用于两名成人受者可能会对等待名单产生显著影响。正确选择供体和受者对于全右半肝和全左半肝劈离后的良好结果至关重要。右叶成人对成人活体肝移植(LDLT)本质上就是一次全右半肝和全左半肝劈离。然而,LDLT技术尚未用于全右半肝和全左半肝劈离。
我们使用LDLT技术对一名血流动力学稳定的年轻脑死亡供体的全肝进行原位劈离,并将其移植给两名终末期肝病模型评分均为17分的成人受者。通过肝脏的正中平面进行横断,获得一个右叶移植物和一个左叶移植物。
两名受者术后恢复均顺利。随访10个月时,两名受者情况良好,肝功能正常。
基于亲属活体肝移植的理念,本病例探讨了全右半肝和全左半肝原位肝劈离的技术可行性。