叶酸偶联脂质体在类风湿关节炎大鼠模型中靶向并递送至免疫细胞的治疗药物。
Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis.
机构信息
College of Engineering & Science, Louisiana Tech University, Ruston, LA 71272, USA.
Department of Chemistry, Centre for Biosciences & Biomedical Engineering, Indian Institute of Technology, Indore, 453 552 Madhya Pradesh, India.
出版信息
Nanomedicine (Lond). 2017 Oct;12(20):2441-2451. doi: 10.2217/nnm-2017-0166. Epub 2017 Sep 20.
AIM
We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation.
MATERIALS & METHODS: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis.
RESULTS
Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups.
CONCLUSION
Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis.
目的
我们试图制备一种叶酸靶向脂质体（Fol-liposome），使其能够选择性地靶向炎症区域。
材料与方法
采用包裹 DiD 荧光染料或倍他米松（BM）的 Fol-liposome 来对佐剂诱导的类风湿关节炎大鼠模型进行成像和治疗。
结果
Fol-liposome 比非靶向脂质体更选择性地在关节炎大鼠的爪子中积累。当这些 Fol-liposome 用于包裹 BM 并施用于关节炎大鼠时，与未治疗或未靶向含有 BM 的脂质体组相比，动物的爪子肿胀程度较低，关节炎评分较低，骨质侵蚀减少，脾肿大减轻，体重保持较好。
结论
Fol-liposome 可以选择性地将成像和治疗剂递送至类风湿关节炎大鼠模型中的炎症部位。
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