Rekvava M, Dundua T, Kobulia M, Javashvili L, Giorgadze E
Cortex Clinic ltd, Tbilisi, Georgia; National Institute of Endocrinology, Tbilisi, Georgia.
Georgian Med News. 2017 Sep(270):46-50.
Metabolic syndrome and nodular pathology of the thyroid gland is a widespread problem nowadays. Recently there has been a notable coincidence between metabolic syndrome and nodular pathology of thyroid gland. Hence, it is interesting to reveal the connection between these two diseases. It is possible that insulin-like growth factor system (IGF), namely IGF 1 is connecting link between metabolic syndrome and nodular pathology of thyroid gland, because IGF1 stimulates growth and proliferation of cells in the body. We have investigated18-82 years of age 71 patients. group 1 n27- subjects with thyroid nodular disease, and metabolic syndrome, group 2 n31- subjects with thyroid nodular disease and without metabolic syndrome. group 3 n13 - subjects with metabolic syndrome and no thyroid pathology. In all groups were assessed thyroid structural data, defined parameters of carbohydrate metabolism, thyroid function and blood concentration of IGF1. In patients with hyperinsulinemia IGF 1 was noted in normal or reduced concentration. In I group IGF1 was normal in 70,4% (n=19), decreased in 29,6% (n=8), In II group was normal in 77,4 % (n=24), decreased in 22,6% (n=7) and in III group was normal in 76,9% (n=10), decreased in 23,1% (n=3). Increase of IGF 1 in patients with thyroid nodular disease patients was not noted. Statistically significant connection between IGF1 and thyroid nodules was not revealed. For the further investigation of this connection we plan to measure IGF1 in the thyroid histological samples in the future studies.
代谢综合征与甲状腺结节病变是当今一个普遍存在的问题。近来，代谢综合征与甲状腺结节病变之间存在显著的相关性。因此，揭示这两种疾病之间的联系很有意思。胰岛素样生长因子系统（IGF），即IGF 1，有可能是代谢综合征与甲状腺结节病变之间的联系纽带，因为IGF1能刺激体内细胞的生长和增殖。我们对71例年龄在18至82岁的患者进行了研究。第1组n = 27，为患有甲状腺结节疾病且伴有代谢综合征的受试者；第2组n = 31，为患有甲状腺结节疾病但无代谢综合征的受试者；第3组n = 13，为患有代谢综合征但无甲状腺病变的受试者。对所有组均评估了甲状腺结构数据、碳水化合物代谢的定义参数、甲状腺功能以及IGF1的血浓度。在高胰岛素血症患者中，IGF 1浓度正常或降低。在第1组中，70.4%（n = 19）的患者IGF1正常，29.6%（n = 8）的患者IGF1降低；在第2组中，77.4%（n = 24）的患者IGF1正常，22.6%（n = 7）的患者IGF1降低；在第3组中，76.9%（n = 10）的患者IGF1正常，23.1%（n = 3）的患者IGF1降低。未发现甲状腺结节疾病患者的IGF 1升高。未揭示IGF1与甲状腺结节之间具有统计学意义的联系。为了进一步研究这种联系，我们计划在未来的研究中测量甲状腺组织学样本中的IGF1。
