Salehipour Mehdi, Monabbati Ahmad, Ensafdaran Mohammad Reza, Adib Ali, Babaei Amir Hossein
Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
J Nephropathol. 2017 Jul;6(3):157-162. doi: 10.15171/jnp.2017.27. Epub 2017 Feb 3.
Several studies have previously been performed to promote kidney healing after injuries. Objectives: The aim of this study was to investigate the effect of zinc on renal healing after traumatic injury in rats.
Forty healthy female rats were selected and one of their kidneys was incised. Half of the incisions were limited only to the cortex (renal injury type I) and the other ones reached the pelvocalyceal system of the kidney (renal injury type II). All the rats in the zinc treated group (case group) received 36.3 mg zinc sulfate (contained 8.25 mg zinc) orally. After 28 days, the damaged kidneys were removed for histopathological studies.
In the rats with type I injury, kidney inflammation of the case group was significantly lower than that of the control group. However, the result was not significant in rats with type II injury. Tissue loss and granulation tissue formation were significantly lower in the case group than the control group in both type I and II kidney injuries.
Overall, Zinc can contribute to better healing of the rat's kidneys after a traumatic injury.
此前已开展多项研究以促进肾脏损伤后的愈合。目的：本研究旨在探讨锌对大鼠创伤性肾损伤后肾脏愈合的影响。
选取40只健康雌性大鼠，切开其中一侧肾脏。一半切口仅局限于皮质（I型肾损伤），另一半切口延伸至肾脏的肾盂肾盏系统（II型肾损伤）。锌治疗组（病例组）的所有大鼠口服36.3毫克硫酸锌（含8.25毫克锌）。28天后，取出受损肾脏进行组织病理学研究。
在I型损伤大鼠中，病例组的肾脏炎症明显低于对照组。然而，在II型损伤大鼠中，结果不显著。在I型和II型肾损伤中，病例组的组织损失和肉芽组织形成均显著低于对照组。
总体而言，锌有助于大鼠创伤性肾损伤后更好地愈合。
