Zhou Fang-Fang, Liu Yun-Hai, Ge Peng-Cheng, Chen Zhao-Hong, Ding Xiao-Qing, Liu Jie-Yin, Jia Qiao-Wei, An Feng-Hui, Li Li-Hua, Wang Lian-Sheng, Ma Wen-Zhu, Yang Zhi-Jian, Jia En-Zhi
Department of Cardiovascular Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Emergency Medcine, the First People's Hospital of Jining, Jining, China.
Cell Physiol Biochem. 2017;43(3):1247-1257. doi: 10.1159/000481765. Epub 2017 Oct 5.
The diameters of the coronary arteries have been suggested to be a potential predictor of coronary artery disease (CAD). However, whether the diameters of the coronary arteries are associated with the coronary lesion severity on angiography has not been determined.
One hundred sixty-seven consecutive adult patients (109 men and 58 women) aged 31-84 years who underwent coronary angiography for suspected or known CAD were enrolled. The known catheter tip diameter was used as the calibration to measure the diameters of coronary arteries, and the severity of coronary lesions was evaluated with the vessel score and Gensini score.
In patients with a higher vessel score and Gensini score, the diameters of the left main (LM), left anterior descending (LAD), left circumflex (LCX), and right coronary arteries (RCA) were smaller (all p<0.05) than those in patients with lower scores. Multiple linear regression analysis indicated that the average coronary artery diameter was significantly associated with the Gensini score (β=-0.444, p<0.00001). Moreover, the diameters of the coronary arteries were potential predictors of CAD, with areas under the receiver operating characteristic curves of 0.268 for average diameter (95% confidence interval [CI]: 0.183-0.353, p<0.00001), 0.356 for the LM diameter (95% CI: 0.266-0.445, p=0.005), 0.214 for the LAD diameter (95% CI: 0.136-0.291, p<0.00001), 0.366 for the LCX diameter (95% CI: 0.271-0.461, p=0.009), and 0.346 for the RCA diameter (95% CI: 0.245-0.447, p=0.003).
The diameters of coronary arteries are inversely associated with the severity of CAD.
冠状动脉直径被认为是冠状动脉疾病（CAD）的一个潜在预测指标。然而，冠状动脉直径与血管造影显示的冠状动脉病变严重程度之间是否存在关联尚未确定。
连续纳入167例年龄在31 - 84岁之间因疑似或已知CAD而行冠状动脉造影的成年患者（109例男性和58例女性）。使用已知的导管尖端直径作为校准来测量冠状动脉直径，并通过血管评分和Gensini评分评估冠状动脉病变的严重程度。
血管评分和Gensini评分较高的患者，其左主干（LM）、左前降支（LAD）、左旋支（LCX）和右冠状动脉（RCA）的直径比评分较低的患者更小（所有p<0.05）。多元线性回归分析表明，冠状动脉平均直径与Gensini评分显著相关（β=-0.444，p<0.00001）。此外，冠状动脉直径是CAD的潜在预测指标，平均直径的受试者工作特征曲线下面积为0.268（95%置信区间[CI]：0.183 - 0.353，p<0.00001），LM直径为0.356（95%CI：0.266 - 0.445，p = 0.005），LAD直径为0.214（95%CI：0.136 - 0.291，p<0.00001），LCX直径为0.366（95%CI：0.271 - 0.461，p = 0.009），RCA直径为0.346（95%CI：0.245 - 0.447，p = 0.003）。
冠状动脉直径与CAD的严重程度呈负相关。
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