衔接蛋白 p66Shc 在肾脏病变中的作用。
Role of adaptor protein p66Shc in renal pathologies.
机构信息
Cardiovascular Center, Medical College of Wisconsin , Milwaukee, Wisconsin.
Department of Medicine, Medical College of Wisconsin , Milwaukee, Wisconsin.
出版信息
Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F143-F153. doi: 10.1152/ajprenal.00414.2017. Epub 2017 Oct 4.
Abstract
p66Shc is one of the three adaptor proteins encoded by the Shc1 gene, which are expressed in many organs, including the kidney. Recent studies shed new light on several key questions concerning the signaling mechanisms mediated by p66Shc. The central goal of this review article is to summarize recent findings on p66Shc and the role it plays in kidney physiology and pathology. This article provides a review of the various mechanisms whereby p66Shc has been shown to function within the kidney through a wide range of actions. The mitochondrial and cytoplasmic signaling of p66Shc, as it relates to production of reactive oxygen species (ROS) and renal pathologies, is further discussed.
摘要
p66Shc 是由 Shc1 基因编码的三种衔接蛋白之一，在许多器官中表达，包括肾脏。最近的研究为 p66Shc 介导的信号转导机制的几个关键问题提供了新的线索。本文的主要目的是总结 p66Shc 的最新发现及其在肾脏生理和病理中的作用。本文综述了 p66Shc 在肾脏中通过广泛的作用方式发挥作用的各种机制。进一步讨论了 p66Shc 的线粒体和细胞质信号转导与活性氧（ROS）的产生和肾脏病理的关系。
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