免疫相关性结肠炎罕见病例。
Unusual case of immune-related colitis.
作者信息
Issa Meltiady, Milioglou Ioannis
机构信息
Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
BMJ Case Rep. 2017 Oct 4;2017:bcr-2017-221319. doi: 10.1136/bcr-2017-221319.
The cancer immunotherapy field has had many promising developments in recent years. Checkpoint inhibitors are good examples of that. This new class of medications comes with a new constellation of side effects that require early recognition and management. Here we present a patient with metastatic adenocarcinoma on pembrolizumab who was admitted to the hospital for colitis. This was found to be an immune-related adverse event from pembrolizumab. We discuss our work-up and approach to the diagnosis, then highlight important treatment pearls for internal medicine physicians who are increasingly taking care of such patients.
近年来，癌症免疫治疗领域取得了许多令人鼓舞的进展。检查点抑制剂就是很好的例子。这类新型药物伴随着一系列新的副作用，需要早期识别和处理。在此，我们介绍一名接受派姆单抗治疗的转移性腺癌患者，该患者因结肠炎入院。这被发现是派姆单抗引起的免疫相关不良事件。我们讨论了我们的检查方法和诊断途径，然后强调了对于越来越多地照料此类患者的内科医生来说重要的治疗要点。
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