Synthesis of Some New Tetrahydropyrimidine Derivatives as Possible Antibacterial Agents.

Heterocyclic compounds containing a pyrimidine nucleus are of special interests thanks to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivatives (1-10) were synthesized via Biginelli reaction using HCl or DABCO as a catalyst with good yields. All structures of products were confirmed by IR, H NMR and C NMR spectroscopy. The antibacterial activity of some synthesized compounds was investigated against (ATCC 6538), (ATCC 12228) (ATCC14579) (ATCC 25922), (ATCC 13883) and (PAO1) bacteria. Some of these compounds such as 8 and 10 exhibited a good to significant antibacterial activity.