Miroshnichenko I I, Kudrin V S, Raevskiĭ K S
Farmakol Toksikol. 1988 Mar-Apr;51(2):26-9.
Haloperidol (1 mg/kg) was shown to increase significantly the dopamine (DA) turnover in n. accumbens and striatum and to a lesser degree in frontal cortex and hypothalamus of the rat brain; to decrease the noradrenaline content in hypothalamus. Sulpiride (50 mg/kg) slightly increased DA turnover in striatum and hypothalamus and lowered the serotonin (5-HT) content in frontal cortex. Carbidine (25 mg/kg) was found to increase DA turnover in frontal cortex, striatum and hypothalamus to a greater degree than haloperidol; 5-HT turnover was increased in all the cerebral regions. The results obtained indicated that the atypical neuroleptic drug carbidine exerts the predominant effect on the frontal cortex, the serotoninergic component being clearly pronounced.
已表明，氟哌啶醇（1毫克/千克）可显著增加大鼠脑伏隔核和纹状体中的多巴胺（DA）周转率，在额叶皮质和下丘脑的增加程度较小；可降低下丘脑去甲肾上腺素含量。舒必利（50毫克/千克）可轻微增加纹状体和下丘脑的DA周转率，并降低额叶皮质中5-羟色胺（5-HT）含量。已发现卡比丹（25毫克/千克）比氟哌啶醇更能显著增加额叶皮质、纹状体和下丘脑的DA周转率；在所有脑区中5-HT周转率均增加。所获结果表明，非典型抗精神病药物卡比丹对额叶皮质发挥主要作用，其5-羟色胺能成分表现明显。
