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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Cerniglia C E, Hansen E B, Lambert K J, Korfmacher W A, Miller D W

National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.

Xenobiotica. 1988 Mar;18(3):301-12. doi: 10.3109/00498258809041666.

Strains of the fungus Cunninghamella elegans ATCC 9245 and 36112 were tested for their ability to transform the antihistamines methapyrilene (I), thenyldiamine (II) and tripelennamine (III). 2. Antihistamine metabolites were isolated by h.p.l.c., and identified by their 1H-n.m.r. and mass spectral properties. 3. All three drugs were transformed by both C. elegans strains to N-oxidized and N-demethylated derivatives. Metabolism during 96 h of incubation amounted to 85% for (I), 64% for (II), and 83% for (III). Metabolites soluble in organic solvents amounted to 62% to 86% of the total metabolism; approximately 88% to 95% of the organic-soluble metabolites were N-oxide derivatives of each antihistamine.

Cerniglia C E, Hansen E B, Lambert K J, Korfmacher W A, Miller D W

National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.

Xenobiotica. 1988 Mar;18(3):301-12. doi: 10.3109/00498258809041666.

Strains of the fungus Cunninghamella elegans ATCC 9245 and 36112 were tested for their ability to transform the antihistamines methapyrilene (I), thenyldiamine (II) and tripelennamine (III). 2. Antihistamine metabolites were isolated by h.p.l.c., and identified by their 1H-n.m.r. and mass spectral properties. 3. All three drugs were transformed by both C. elegans strains to N-oxidized and N-demethylated derivatives. Metabolism during 96 h of incubation amounted to 85% for (I), 64% for (II), and 83% for (III). Metabolites soluble in organic solvents amounted to 62% to 86% of the total metabolism; approximately 88% to 95% of the organic-soluble metabolites were N-oxide derivatives of each antihistamine.