[新疆维吾尔族和汉族人群中KCNE1和KCNE4基因多态性与心房颤动的关联]
[Association of KCNE1 and KCNE4 gene polymorphisms with atrial fibrillation among Uygur and Han Chinese populations in Xinjiang].
作者信息
Miao Haijun, Zhou Xiaohui, Kabinur Keyimu, Zou Ting, Palida Abulizi, Tang Baopeng
机构信息
First Department of Internal Medicine for Cadres, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Oct 10;34(5):743-748. doi: 10.3760/cma.j.issn.1003-9406.2017.05.027.
OBJECTIVE
To assess the association of KCNE1 (rs1805127) and KCNE4 (rs12621643) polymorphisms with atrial fibrillation (AF) among ethnic Uygur and Han Chinese in Xinjiang.
METHODS
A case-control study was carried out. The patients and controls were selected based on ethnicity, gender and age with an 1:1 ratio. DNA was extracted from peripheral blood samples. Genotypes of KCNE1 (rs1805127) and KCNE4 (rs12621643) were determined with a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
RESULTS
Multivariate Logistic regression analysis showed KCNE1 (rs1805127) to be an independent risk factor for AF among Uygurs, while KCNE4 (rs12621643) was a risk factor for both Uygur and Han patients with AF (P < 0.05). The population attributable risk percentage (PARc%) of obstructive sleep apnea hpoventilation syndrome, obesity, hypertension, cholesterol, Hcy, hs-CRP, IL-6, KCNE1 (rs1805127) and KCNE4 (rs12621643) were 9.68%, 12.06%, 15.76%, 6.91%, 11.37%, 17.78%, 9.31%, 11.27% and 6.46% among the Uygurs, respectively. The PARc% of drinking, hypertension, cholesterol, Hcy, hs-CRP, IL-6, and KCNE4 (rs12621643) were 12.94%, 14.48%, 7.24%, 8.49%, 17.29%, 9.49% and 7.41% among Hans.
CONCLUSION
The KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (rs12621643) was an independent risk factor for AF among both Uygurs and Hans. Management of the risk factors of AF based on testing of "risk genes" may have an impact on the prevention and treatment of AF.
目的
评估新疆维吾尔族和汉族人群中KCNE1（rs1805127）和KCNE4（rs12621643）基因多态性与心房颤动（AF）的相关性。
方法
开展一项病例对照研究。根据种族、性别和年龄按1:1比例选取患者和对照。从外周血样本中提取DNA。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析法测定KCNE1（rs1805127）和KCNE4（rs12621643）的基因型。
结果
多因素Logistic回归分析显示，KCNE1（rs1805127）是维吾尔族人群发生AF的独立危险因素，而KCNE4（rs12621643）是维吾尔族和汉族AF患者的危险因素（P<0.05）。维吾尔族人群中阻塞性睡眠呼吸暂停低通气综合征、肥胖、高血压、胆固醇、同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、KCNE1（rs1805127）和KCNE4（rs12621643）的人群归因危险百分比（PARc%）分别为9.68%、12.06%、15.76%、6.91%、11.37%、17.78%、9.31%、11.27%和6.46%。汉族人群中饮酒、高血压、胆固醇、Hcy、hs-CRP、IL-6和KCNE4（rs12621643）的PARc%分别为12.94%、14.48%、7.24%、8.49%、17.29%、9.49%和7.41%。
结论
KCNE1（rs1805127）似乎是维吾尔族人群发生AF的独立危险因素。而KCNE4（rs12621643）是维吾尔族和汉族人群发生AF的独立危险因素。基于“风险基因”检测对AF危险因素进行管理可能会对AF的防治产生影响。
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