Finnegan K T, Ricaurte G A, Ritchie L D, Irwin I, Peroutka S J, Langston J W
Institute for Medical Research, San Jose, CA 95128.
Brain Res. 1988 Apr 26;447(1):141-4. doi: 10.1016/0006-8993(88)90974-2.
Recent studies suggest that 3,4-methylenedioxymethylamphetamine (MDMA), when administered subcutaneously, is toxic to central serotonergic neurons in rats. Because humans typically self-administer this drug orally, we compared this route to the s.c. route of administration. Orally administered MDMA produced a dose-related depletion of serotonin comparable to that produced by the s.c. route. These findings suggest that MDMA, when given orally, retains it neurotoxic activity and that humans using MDMA may be at risk for developing a persistent depletion of brain serotonin.
近期研究表明，3,4－亚甲基二氧甲基苯丙胺（摇头丸）皮下给药时，对大鼠中枢5-羟色胺能神经元有毒性。由于人类通常口服这种药物，我们将此给药途径与皮下给药途径进行了比较。口服摇头丸产生了与皮下给药相当的、与剂量相关的5-羟色胺耗竭。这些发现表明，口服摇头丸时保留了其神经毒性活性，使用摇头丸的人类可能有发生脑内5-羟色胺持续耗竭的风险。
