围手术期红细胞输血与胰腺腺癌患者长期生存不良相关。
Perioperative Red Blood Cell Transfusion Is Associated with Poor Long-term Survival in Pancreatic Adenocarcinoma.
作者信息
Abe Tomoyuki, Amano Hironobu, Hanada Keiji, Minami Tomoyuki, Yonehara Shuji, Hattori Minoru, Kobayashi Tsuyoshi, Fukuda Toshikatsu, Nakahara Masahiro, Ohdan Hideki, Noriyuki Toshio
机构信息
Department of Surgery, Onomichi General Hospital, Onomichi, Japan.
Department of Surgery, Onomichi General Hospital, Onomichi, Japan
出版信息
Anticancer Res. 2017 Oct;37(10):5863-5870. doi: 10.21873/anticanres.12031.
BACKGROUND/AIM: Perioperative red blood cell transfusion (RBCT) can negatively affect the host's immune system. We investigated the effects of perioperative RBCT on long-term survival among patients with pancreatic ductal adenocarcinoma (PDAC).
PATIENTS AND METHODS
We retrospectively evaluated 148 patients with PDAC who underwent surgery with curative intent (33 who received RBCTs and 115 who did not). Significant prognostic variables on univariate analysis were subjected to multivariate analyses using a Cox proportional hazard regression model.
RESULTS
Both groups exhibited significant differences in age, preoperative haemoglobin levels, carbohydrate antigen 19-9 levels, maximum tumour size, tumour staging, operative time, intraoperative blood loss, major vascular resection, and the proportion of pancreaticoduodenectomies performed. Patients who underwent RBCTs exhibited significantly poorer overall survival (p<0.001) and recurrence-free survival (p<0.001) compared to patients who did not.
CONCLUSION
Perioperative RBCT was associated with poorer long-term survival among patients with PDAC who underwent surgery with curative intent.
背景/目的：围手术期红细胞输注（RBCT）会对宿主免疫系统产生负面影响。我们研究了围手术期RBCT对胰腺导管腺癌（PDAC）患者长期生存的影响。
患者与方法
我们回顾性评估了148例接受根治性手术的PDAC患者（33例接受了RBCT，115例未接受）。单因素分析中有显著预后变量的患者采用Cox比例风险回归模型进行多因素分析。
结果
两组在年龄、术前血红蛋白水平、糖类抗原19-9水平、最大肿瘤大小、肿瘤分期、手术时间、术中失血、主要血管切除以及胰十二指肠切除术的比例方面均存在显著差异。与未接受RBCT的患者相比，接受RBCT的患者总生存期（p<0.001）和无复发生存期（p<0.001）明显更差。
结论
围手术期RBCT与接受根治性手术的PDAC患者较差的长期生存相关。
Zotero 插件