长效生长抑素治疗佐林格-埃利森综合征患者的副肿瘤性库欣综合征。
Long acting somatostatin treatment of paraneoplastic Cushing's syndrome in a case of Zollinger-Ellison syndrome.
作者信息
Ruszniewski P, Girard F, Benamouzig R, Mignon M, Bonfils S
机构信息
Clinique des Maladies de l'Appareil Digestif, Hôpital Bichat, Paris, France.
出版信息
Gut. 1988 Jun;29(6):838-42. doi: 10.1136/gut.29.6.838.
Abstract
Cushing's syndrome, caused by ectopic ACTH production during Zollinger-Ellison syndrome, raises difficult therapeutic problems. We report a case of clinical and biological efficacy of long acting somatostatin (SMS) in this condition. In a short term study with 200 micrograms SMS bid, symptoms of hypercorticism disappeared while cortisol and ACTH serum concentrations fell below the normal values. Longterm treatment was instituted with 50 micrograms SMS bid. Excellent clinical efficacy as well as normal cortisol and ACTH serum concentrations were maintained during the nine month follow up. Lipotrophic hormone (LPH) serum concentration remained raised. No decrease in size of hepatic metastases was observed. Long acting somatostatin analogues may be useful in endocrine paraneoplastic syndromes.
摘要
佐林格-埃利森综合征期间异位促肾上腺皮质激素（ACTH）分泌导致的库欣综合征引发了棘手的治疗问题。我们报告了长效生长抑素（SMS）在这种情况下的临床和生物学疗效的一个病例。在一项短期研究中，每天两次给予200微克SMS，皮质醇增多症的症状消失，同时血清皮质醇和ACTH浓度降至正常值以下。开始长期治疗，每天两次给予50微克SMS。在9个月的随访期间，维持了良好的临床疗效以及正常的血清皮质醇和ACTH浓度。血清促脂解素（LPH）浓度仍升高。未观察到肝转移灶大小减小。长效生长抑素类似物可能在内分泌副肿瘤综合征中有用。
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本文引用的文献
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Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature.胰岛细胞癌患者并发库欣综合征和佐林格-埃利森综合征。病例报告及文献复习。
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