天山堇菜中的生物碱成分。
Alkaloid constituents from Viola tianschanica.
作者信息
Chen Qi-Bin, Aisa Haji Akber
机构信息
Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.
Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
出版信息
Phytochemistry. 2017 Dec;144:233-242. doi: 10.1016/j.phytochem.2017.09.011. Epub 2017 Oct 3.
Eighteen previously undescribed alkaloids, tishaviolamines A-J, including eight pairs of enantiomers, together with two known benzylisoquinoline alkaloids, (-)-bicuculline and (-)-corlumine, were isolated from Viola tianschanica. Among them, tishaviolamine A-E were demonstrated to possess three types of unpresented skeletons. The structures of these alkaloids were established by comprehensive analyses of the 1D, 2D-NMR and (+)HRESIMS data. The absolute configurations of enantiomers were determined by comparing their calculated ECD spectra with the experimental ones. The menin-mixed lineage leukemia 1 protein-protein interaction inhibitory effect of the isolated compounds were also measured.
从天山堇菜中分离出18种以前未描述过的生物碱，即铁沙维胺A-J，包括8对对映体，以及两种已知的苄基异喹啉生物碱，（-）-荷包牡丹碱和（-）-柯鲁明。其中，铁沙维胺A-E被证明具有三种未呈现的骨架类型。通过对一维、二维核磁共振和（+）高分辨电喷雾电离质谱数据的综合分析确定了这些生物碱的结构。通过将计算得到的电子圆二色谱与实验数据进行比较，确定了对映体的绝对构型。还测定了分离得到的化合物对脑膜混合谱系白血病1蛋白-蛋白相互作用的抑制作用。
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