Kumai Toshifumi
Graduate School of Oral Medicine, Matsumoto Dental University, Nagano 399-0781, Japan.
Biophys Physicobiol. 2017 Sep 14;14:147-152. doi: 10.2142/biophysico.14.0_147. eCollection 2017.
It is established knowledge that the action potential event of nerves is formed by the combination of a phasic inward Na current and a following outward K current which increases gradually. These changes in current are commonly referred to as conductance changes of channels for Na and K with time. On the other hand, electric requirements for action potential generation in phenomena such as anode break excitation, hyperpolarizing break stimulation and accommodation, strongly suggest an existence of an inductance factor in the plasma membrane of nerves. In this study, the possibility that the Na channel could be simulated by a circuit composed serially of resistance (R), inductance (L), and capacitance (C) was examined using a computer simulation. Electric responses of the RLC circuit ( ≥ ) to step voltages are as followings: (1) A transient potential is produced on the inductor, (2) the circuit current simulates well the Na current manner, and (3) time course of the capacitor potential resembles the K current change.
神经动作电位事件是由阶段性内向钠电流和随后逐渐增加的外向钾电流相结合形成的,这是已确定的知识。电流的这些变化通常被称为钠通道和钾通道的电导率随时间的变化。另一方面,在诸如阳极断电兴奋、超极化断电刺激和适应等现象中,动作电位产生的电学要求强烈表明神经质膜中存在电感因素。在本研究中,使用计算机模拟研究了钠通道是否可以由串联的电阻(R)、电感(L)和电容(C)组成的电路模拟的可能性。RLC电路(≥)对阶跃电压的电响应如下:(1)电感上产生瞬态电位,(2)电路电流很好地模拟钠电流方式,(3)电容电位的时间进程类似于钾电流变化。