Farsi Farnaz, Heshmati Javad, Janani Leila, Irandoost Pardis, Mesri Alamdari Naeimeh, Keshtkar Abbasali, Akbari Abolfazl, Vafa Mohammadreza
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMJ Open. 2017 Oct 8;7(10):e016841. doi: 10.1136/bmjopen-2017-016841.
Inflammation, as a critical factor, can cause numerous chronic diseases by creating various proinflammatory cytokines. Coenzyme Q10 (CoQ10) can potentially exert an anti-inflammatory agent; in turn, this agent can reduce the systemic inflammatory response. The aims of this study are to conduct a comprehensive systematic review and a meta-analysis for the determination of the CoQ10 efficacy on the changes in serum interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) levels in unhealthy subjects.
We will conduct an electronic search for articles published between January 1990 and January 2017 using a prespecified search strategy in MEDLINE, SCOPUS, EMBASE, CENTRAL and Web of Science.Our search will focus only on randomised controlled clinical trials in unhealthy subjects that employ either a parallel or a crossover design; this search will involve concurrent control groups. The primary outcomes of the literature are to determine the CoQ10 efficacy on the changes in the serum IL-6 and the TNF-α levels in unhealthy subjects. Secondary outcomes such as body mass index, serum adiponectin and high-sensitivity C-reactive protein levels, lipid profile and the heterogeneity assessment of the primary studies will be evaluated. The stages of screen articles, the extracts of relevant data and the assessment of study quality using the Cochrane risk of bias tool will be conducted independently by the two reviewers. Any disagreement will be resolved by discussion with a third person. If the number of eligible studies is sufficient, we will carry out a meta-analysis according to both outcomes.
This study is the protocol for a systematic review and no ethics approval is needed. The findings from the full systematic review will be published in a peer-reviewed journal, and they will also be exhibited at national/international academic and clinical conferences.
CRD42016052200.
炎症作为一个关键因素，可通过产生多种促炎细胞因子引发众多慢性疾病。辅酶Q10（CoQ10）可能发挥抗炎作用；反过来，这种物质可减轻全身炎症反应。本研究旨在进行全面的系统评价和荟萃分析，以确定CoQ10对不健康受试者血清白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平变化的疗效。
我们将使用预先设定的检索策略，在MEDLINE、SCOPUS、EMBASE、CENTRAL和科学网中检索1990年1月至2017年1月发表的文章。我们的检索将仅聚焦于不健康受试者的随机对照临床试验，这些试验采用平行或交叉设计；此次检索将纳入同期对照组。文献的主要结局是确定CoQ10对不健康受试者血清IL-6和TNF-α水平变化的疗效。将评估次要结局，如体重指数、血清脂联素和高敏C反应蛋白水平、血脂谱以及主要研究的异质性评估。两位评价者将独立进行筛选文章阶段、提取相关数据以及使用Cochrane偏倚风险工具评估研究质量。任何分歧将通过与第三人讨论解决。如果符合条件的研究数量足够，我们将根据这两个结局进行荟萃分析。
本研究是一项系统评价的方案，无需伦理批准。全面系统评价的结果将发表在同行评审期刊上，也将在国家/国际学术和临床会议上展示。
CRD42016052200。
