《独联体国家成年人慢性阻塞性肺疾病、支气管哮喘和变应性鼻炎：CORE 研究的原理和设计》。
Chronic obstructive pulmonary disease, bronchial asthma and allergic rhinitis in the adult population within the commonwealth of independent states: rationale and design of the CORE study.
机构信息
National Institute of Phthisiology and Pulmonology F.G. Yanovsky of NAMS, Kiev, Ukraine.
Semey State Medical University, Almaty, Kazakhstan.
出版信息
BMC Pulm Med. 2017 Oct 10;17(1):131. doi: 10.1186/s12890-017-0471-x.
BACKGROUND
Main treatable Chronic Respiratory Diseases (CRDs) like Chronic Obstructive Pulmonary Disease (COPD), Bronchial Asthma (BA) and Allergic Rhinitis (AR) are underdiagnosed and undertreated worldwide. CORE study was aimed to assess the point prevalence of COPD, BA and AR in the adult population of major cities of Commonwealth of Independent States (CIS) countries - Azerbaijan, Kazakhstan, and Ukraine based on study questionnaires and/or spirometry, and to document risk factors, characterize the COPD, BA and AR population to provide a clearer "epidemiological data".
METHODS
A descriptive, cross-sectional, population-based epidemiological study conducted from 2013 to 2015 with two-stage cluster geographical randomization. Interviewers conducted face-to-face visits at respondent's household after informed consent and eligibility assessment including interviews, anthropometry, spirometry (with bronchodilator test) and completion of disease-specific questionnaires.
RESULTS
Two thousand eight hundred forty-two respondents (Ukraine: 964 from Ukraine; 945 from Kazakhstan; 933 Azerbaijan) were enrolled. Mean age was 40-42 years and males were 37%-42% across three countries. In Kazakhstan 62.8% were Asians, but in Ukraine and in Azerbaijan 99.7% and 100.0%, respectively, were Caucasians. Manual labourers constituted 40.5% in Ukraine, 22.8% in Kazakhstan and 22.0% in Azerbaijan, while office workers were 16.1%, 31.6% and 36.8% respectively. 51.3% respondents in Ukraine, 64.9% in Kazakhstan and 69.7% in Azerbaijan were married.
CONCLUSION
CORE study collected information that can be supportive for health policy decision makers in allocating healthcare resources in order to improve diagnosis and management of CRDs. The detailed findings will be described in future publications.
TRIAL REGISTRATION
Study Protocol Summary is disclosed at GlaxoSmithKline Clinical Study Register on Jun 06, 2013, study ID 116757 .
背景
慢性阻塞性肺疾病（COPD）、支气管哮喘（BA）和过敏性鼻炎（AR）等主要可治疗的慢性呼吸道疾病在全球范围内都存在诊断不足和治疗不足的情况。CORE 研究旨在评估独联体（CIS）国家主要城市成年人群中 COPD、BA 和 AR 的现患率，基于研究问卷和/或肺量测定法，评估风险因素，并对 COPD、BA 和 AR 人群进行特征描述，以提供更清晰的“流行病学数据”。
方法
这是一项在 2013 年至 2015 年期间进行的描述性、横断面、基于人群的流行病学研究，采用两阶段聚类地理随机化。经过知情同意和资格评估后，调查员在被调查者家中进行面对面访谈，包括访谈、人体测量学、肺量测定法（带支气管扩张剂试验）和完成特定疾病问卷。
结果
共纳入 2842 名受访者（乌克兰 964 名，哈萨克斯坦 945 名，阿塞拜疆 933 名）。平均年龄为 40-42 岁，三个国家的男性比例为 37%-42%。在哈萨克斯坦，62.8%为亚洲人，但在乌克兰和阿塞拜疆，分别有 99.7%和 100.0%为高加索人。体力劳动者在乌克兰占 40.5%，在哈萨克斯坦占 22.8%，在阿塞拜疆占 22.0%，而办公室工作人员在乌克兰、哈萨克斯坦和阿塞拜疆分别占 16.1%、31.6%和 36.8%。51.3%的乌克兰受访者、64.9%的哈萨克斯坦受访者和 69.7%的阿塞拜疆受访者已婚。
结论
CORE 研究收集的信息可以为卫生政策决策者提供支持，以便在分配医疗资源时改善慢性呼吸道疾病的诊断和管理。详细结果将在未来的出版物中描述。
试验注册
研究方案摘要于 2013 年 6 月 6 日在葛兰素史克临床研究注册处公布，研究 ID 为 116757。
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