长期使用苯二氮䓬类药物治疗会增强反向激动剂的作用。 - Suppr | 超能文献

Chronic benzodiazepine treatment increases the effects of inverse agonists.

作者信息

Little H J

机构信息

Department of Pharmacology, Medical School, Bristol, England.

出版信息

Adv Biochem Psychopharmacol. 1988;45:307-23.

Abstract

摘要

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Chronic benzodiazepine treatment increases the effects of inverse agonists.长期使用苯二氮䓬类药物治疗会增强反向激动剂的作用。

Adv Biochem Psychopharmacol. 1988;45:307-23.

2

Non-uniformity of tolerance to the actions of benzodiazepine agonists.对苯二氮䓬类激动剂作用的耐受性不一致。

Adv Biochem Psychopharmacol. 1988;45:355-66.

3

Chronic benzodiazepine treatment increases the effects of the inverse agonist FG7142.长期使用苯二氮䓬类药物治疗会增强反向激动剂FG7142的作用。

Neuropharmacology. 1988 Apr;27(4):383-9. doi: 10.1016/0028-3908(88)90147-5.

4

Down-regulation of benzodiazepine binding to alpha 5 subunit-containing gamma-aminobutyric Acid(A) receptors in tolerant rat brain indicates particular involvement of the hippocampal CA1 region.在耐受大鼠大脑中，苯二氮䓬与含α5亚基的γ-氨基丁酸（A）受体结合的下调表明海马CA1区有特别的参与。

J Pharmacol Exp Ther. 2000 Nov;295(2):689-96.

5

Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance.拮抗剂诱导的海马苯二氮䓬耐受性的功能和结构指标的逆转。

J Pharmacol Exp Ther. 1999 Dec;291(3):932-42.

6

Decreased sensitivity to benzodiazepine receptor agonists and increased sensitivity to inverse agonists following chronic treatments: evidence for separate mechanisms.长期治疗后对苯二氮䓬受体激动剂的敏感性降低以及对反向激动剂的敏感性增加：不同机制的证据。

Adv Biochem Psychopharmacol. 1988;45:337-54.

7

Chronic benzodiazepine administration: effects in vivo and in vitro.

Adv Biochem Psychopharmacol. 1990;46:167-75.

8

Aspects of benzodiazepine receptor structure and function with relevance to drug tolerance and dependence.与药物耐受性和依赖性相关的苯二氮䓬受体结构与功能的各个方面。

Biochem Soc Symp. 1993;59:121-34.

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A search for a new anticonvulsant and anxiolytic benzodiazepine devoid of side effects and tolerance liability.

Adv Biochem Psychopharmacol. 1995;48:75-92.

10

Benzodiazepine tolerance and dependence: GABAA receptor complex locus of change.苯二氮䓬类药物耐受性与依赖性：γ-氨基丁酸A型受体复合物的变化位点

Biochem Soc Symp. 1993;59:135-51.

引用本文的文献

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Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs.尼群地平可减少苯二氮䓬类药物戒断性癫痫发作，但不能减少苯二氮䓬类药物耐受性的形成或戒断症状。

Br J Pharmacol. 1990 Nov;101(3):691-7. doi: 10.1111/j.1476-5381.1990.tb14142.x.