Division of Pediatric Gastroenterology, Hepatology and Nutrition, Lucile Packard Children's Hospital, Palo Alto, Stanford, CA 94304, USA.
Department of Medicine, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Nutrients. 2017 Oct 16;9(10):1127. doi: 10.3390/nu9101127.
Malnutrition has become a dangerously common problem in children with chronic liver disease, negatively impacting neurocognitive development and growth. Furthermore, many children with chronic liver disease will eventually require liver transplantation. Thus, this association between malnourishment and chronic liver disease in children becomes increasingly alarming as malnutrition is a predictor of poorer outcomes in liver transplantation and is often associated with increased morbidity and mortality. Malnutrition requires aggressive and appropriate management to correct nutritional deficiencies. A comprehensive review of the literature has found that infants with chronic liver disease (CLD) are particularly susceptible to malnutrition given their low reserves. Children with CLD would benefit from early intervention by a multi-disciplinary team, to try to achieve nutritional rehabilitation as well as to optimize outcomes for liver transplant. This review explains the multifactorial nature of malnutrition in children with chronic liver disease, defines the nutritional needs of these children, and discusses ways to optimize their nutritional.
营养不良已成为慢性肝病儿童中一个危险的普遍问题，对神经认知发育和生长产生负面影响。此外，许多患有慢性肝病的儿童最终需要进行肝移植。因此，随着营养不良成为肝移植不良结局的预测因素，并且常与发病率和死亡率增加相关，这种儿童营养不良与慢性肝病之间的关联变得越来越令人担忧。营养不良需要积极和适当的管理来纠正营养缺陷。文献综述发现，由于婴儿储备量低，患有慢性肝病 (CLD) 的婴儿尤其容易发生营养不良。多学科团队的早期干预将使 CLD 患儿受益，以尝试实现营养康复，并优化肝移植的结果。这篇综述解释了慢性肝病儿童营养不良的多因素性质，定义了这些儿童的营养需求，并讨论了优化其营养的方法。
