Antia Camila, Persad Leah, Alikhan Ali
J Drugs Dermatol. 2017 Oct 1;16(10):1043-1046.
Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe and potentially life threatening adverse drug reaction. To help identify DRESS, several criteria have been established; however, there is still a lack of consensus on diagnosis, and clinical judgment is paramount. Here we describe a 24-year-old female who presented with a cutaneous eruption, fever, lymphadenopathy, eosinophilia, facial edema, and elevated liver enzymes four and a half weeks after a 10-day course of Trimethoprim/sulfamethoxazole (TMP/SMX). We used both the RegiSCAR and J-SCAR criteria to show the validity of classifying this case as DRESS, we also comment on the only other three cases, published to date, that had been reported as TMP/SMX induced DRESS. DRESS can be a difficult diagnosis due to its diverse symptomatology and delayed presentation - therefore, high suspicion and exclusion of other causes is key. Use of validated diagnostic criteria can aid the clinician in this regard. In the absence of a well-established therapy, early recognition, withdrawal of suspected drug(s), and supportive care play a crucial role in the management of DRESS.
J Drugs Dermatol. 2017;16(10):1043-1046.
.药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）是一种严重且可能危及生命的药物不良反应。为帮助识别DRESS，已制定了多项标准；然而，在诊断方面仍缺乏共识，临床判断至关重要。在此，我们描述一名24岁女性，在接受为期10天的甲氧苄啶/磺胺甲恶唑（TMP/SMX）治疗四周半后，出现皮肤疹、发热、淋巴结病、嗜酸性粒细胞增多、面部水肿和肝酶升高。我们使用RegiSCAR和J-SCAR标准来证明将该病例分类为DRESS的有效性，我们还对迄今为止已发表的另外三例报告为TMP/SMX诱发DRESS的病例进行了评论。由于DRESS症状多样且出现延迟，其诊断可能具有挑战性——因此，高度怀疑并排除其他病因是关键。在这方面使用经过验证的诊断标准可帮助临床医生。在缺乏成熟治疗方法的情况下，早期识别、停用可疑药物以及支持性治疗在DRESS的管理中起着至关重要的作用。
《皮肤药物学杂志》。2017年；16(10):1043 - 1046。
