Caimi G, Hopps E, Carlisi M, Montana M, Gallà E, Lo Presti R, Siragusa S
Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy.
Dipartimento di Scienze Psicologiche, Pedagogiche e della Formazione, Università di Palermo, Palermo, Italy.
Clin Hemorheol Microcirc. 2018;68(1):51-59. doi: 10.3233/CH-170289.
There is scarcity of information about the hemorheological pattern in subjects with Monoclonal Gammopathy of Undetermined Significance (MGUS). This preliminary research is focused on the behaviour of whole-blood and plasma viscosity, haematocrit and erythrocyte deformability in the above clinical condition. We enrolled 21 MGUS subjects (10 women and 11 men; mean age 66.4 ± 11.6 years). In fasting venous blood we examined whole-blood and plasma viscosity at high and low shear rates, haematocrit, the ratios between whole-blood viscosity (at high and low shear rate) and haematocrit × 100, the ratio between plasma viscosity at low and high shear rate, and the erythrocyte deformability expressed as elongation index. By comparing normal controls to MGUS subjects a significant increase in whole-blood viscosity at high shear rate and in plasma viscosity at low shear rate were observed. In MGUS subjects the ratios between the high and low shear rate blood viscosity and haematocrit × 100, as well as the ratio between the low and high shear rate plasma viscosity were significantly higher. In MGUS subjects a marked decrease in erythrocyte deformability was also observed. The alteration of the hemorheological profile found in these subjects might be involved in the pathogenesis of thromboembolic events, which occur with a high frequency in MGUS.
关于意义未明的单克隆丙种球蛋白病（MGUS）患者血液流变学模式的信息匮乏。这项初步研究聚焦于上述临床情况下全血和血浆粘度、血细胞比容及红细胞变形性的表现。我们招募了21名MGUS患者（10名女性和11名男性；平均年龄66.4±11.6岁）。我们检测了空腹静脉血在高、低剪切速率下的全血和血浆粘度、血细胞比容、全血粘度（高、低剪切速率下）与血细胞比容×100的比值、低剪切速率与高剪切速率下血浆粘度的比值，以及以伸长指数表示的红细胞变形性。通过将正常对照组与MGUS患者进行比较，观察到高剪切速率下全血粘度和低剪切速率下血浆粘度显著增加。在MGUS患者中，高、低剪切速率下血液粘度与血细胞比容×100的比值，以及低、高剪切速率下血浆粘度的比值均显著更高。在MGUS患者中还观察到红细胞变形性明显降低。在这些患者中发现的血液流变学特征改变可能与血栓栓塞事件的发病机制有关，血栓栓塞事件在MGUS中频繁发生。
