SORL1基因多态性与阿尔茨海默病风险之间的关联。

Association between SORL1 polymorphisms and the risk of Alzheimer's disease.

作者信息

Cong Lele, Kong Xiangyi, Wang Jing, Du Jianshi, Xu Zhongxin, Xu Yanan, Zhao Qing

机构信息

Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China.

Institute of Clinical Medicine, Jilin University, Changchun, 130021, China.

出版信息

J Integr Neurosci. 2018;17(2):185-192. doi: 10.31083/JIN-170051.

DOI:10.31083/JIN-170051

PMID:29036834

Abstract

A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin related receptor on Alzheimer’s disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotidepolymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility inAsian populations, (ii) Single nucleotide polymorphism rs689021 was associatedwith decreased risk in Caucasians, and (iii) Single nucleotide polymorphismrs641120 was detected as a decreased risk in both populations. Given thesedata, crucial evidence is provided to demonstrate that a significantrelationship exists between SORL1 polymorphisms and susceptibility to Alzheimer’s disease.

摘要

进行了一项荟萃分析，以基于14项研究（涉及37941例病例和49727项对照研究）确定评估sortilin相关受体单核苷酸多态性对阿尔茨海默病影响的实证数据。分析表明，（i）亚洲人群中，单核苷酸多态性（rs641120、rs1010159）与阿尔茨海默病易感性之间的风险增加，（ii）单核苷酸多态性rs689021与白种人风险降低相关，（iii）在这两个人群中均检测到单核苷酸多态性rs641120风险降低。基于这些数据，提供了关键证据来证明SORL1多态性与阿尔茨海默病易感性之间存在显著关系。