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[运动障碍的神经精神病学]

[Neuropsychiatry Of Movement Disorders].

作者信息

Orjuela-Rojas Juan Manuel, Barrios Vincos Gustavo Adolfo, Martínez Gallego Melisa Alejandra

机构信息

Clínica de Memoria Clínica La Inmaculada, Bogotá, Colombia.

Clínica de Memoria Clínica La Inmaculada, Bogotá, Colombia.

出版信息

Rev Colomb Psiquiatr. 2017 Oct;46 Suppl 1:59-68. doi: 10.1016/j.rcp.2017.05.010. Epub 2017 Jun 20.

Abstract

Movement disorders can be defined as neurological syndromes presenting with excessive or diminished automatic or voluntary movements not related to weakness or spasticity. Both Parkinson's disease (PD) and Huntington's disease (HD) are well-known examples of these syndromes. The high prevalence of comorbid psychiatric symptoms like depression, anxiety, obsessive-compulsive symptoms, hallucinations, delusions, impulsivity, sleep disorders, apathy and cognitive impairment mean that these conditions must be regarded as neuropsychiatric diseases. In this article, we review neuroanatomical (structural and functional), psychopathological and neuropsychological aspects of PD and HD. The role of fronto-subcortical loops in non-motor functions is particularly emphasised in order to understand the clinical spectrum of both diseases, together with the influence of genetic, psychological and psychosocial aspects. A brief description of the main psychopharmacological approaches for both diseases is also included.

摘要

运动障碍可定义为表现为与无力或痉挛无关的自动或自主运动过多或减少的神经综合征。帕金森病(PD)和亨廷顿病(HD)都是这些综合征的著名例子。诸如抑郁、焦虑、强迫症状、幻觉、妄想、冲动、睡眠障碍、冷漠和认知障碍等共病精神症状的高患病率意味着这些疾病必须被视为神经精神疾病。在本文中,我们回顾了帕金森病和亨廷顿病的神经解剖学(结构和功能)、精神病理学和神经心理学方面。为了理解这两种疾病的临床谱,以及遗传、心理和社会心理方面的影响,特别强调了额-皮质下环路在非运动功能中的作用。本文还简要描述了这两种疾病的主要心理药理学方法。

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