激光光生物刺激诱导的大鼠痛觉减退不能被纳洛酮逆转。

Laser photobiostimulation-induced hypoalgesia in rats is not naloxone reversible.

作者信息

Ponnudurai R N, Zbuzek V K, Niu H L, Wu W H

机构信息

UMD-New Jersey Medical School, Department of Anesthesiology, Newark 07103.

出版信息

Acupunct Electrother Res. 1988;13(2-3):109-17. doi: 10.3727/036012988816358697.

DOI:10.3727/036012988816358697

PMID:2904208

Abstract

Laser photobiostimulation (LPBS) at the pulsing frequency of 4 Hz applied to the low resistance point located at the base of the tail of the rat, (Governing Vessel Meridian 1), produced a hypoalgesic effect, measured by tail-flick and hot-plate techniques. Pre-treatment with low dose naloxone (2 mg/kg) did not reverse the hypoalgesic effect of LPBS. High dose naloxone (20 mg/kg) reversed only partially, but significantly, the hypoalgesic effect of LPBS measured by hot-plate, but not that measured by the tail-flick technique. These data suggest that mechanisms other than endogenous opioids may be involved in LPBS-induced hypoalgesia.

摘要

以4Hz的脉冲频率对大鼠尾根部（督脉经1）的低电阻点进行激光光生物刺激（LPBS），通过甩尾和热板技术测量，产生了痛觉减退效应。低剂量纳洛酮（2mg/kg）预处理并未逆转LPBS的痛觉减退效应。高剂量纳洛酮（20mg/kg）仅部分但显著地逆转了通过热板测量的LPBS的痛觉减退效应，而对通过甩尾技术测量的痛觉减退效应则无此作用。这些数据表明，内源性阿片类物质以外的机制可能参与了LPBS诱导的痛觉减退。