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血清脂联素水平降低与非创伤性股骨头坏死患者的疾病严重程度相关。

Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head.

作者信息

Yue Yong-Bin, Liu Xin, Wei Biao-Fang

机构信息

Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province.

Department of Orthopedics, Linyi People's Hospital, Linyi, Shandong Province, People's Republic of China.

出版信息

J Pain Res. 2017 Oct 3;10:2387-2393. doi: 10.2147/JPR.S143036. eCollection 2017.

DOI:10.2147/JPR.S143036
PMID:29042814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5633271/
Abstract

OBJECTIVE: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients. PATIENTS AND METHODS: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA). The radiographic progression was determined by Ficat grading system. The clinical severity was evaluated by visual analog scale (VAS), Harris hip scores (HSSs) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC) scores. RESULTS: Serum APN levels were significantly lower in ONFH patients than in healthy controls. Serum APN levels were significantly lower in patients with Ficat stage 4 ONFH than in patients with stage 3 ONFH, and APN levels in patients with stage 3 were lower compared with stage 2. Serum APN levels were negatively correlated with the Ficat grading system. In addition, serum APN levels were also negatively related to VAS and WOMAC scores and positively associated with HSSs. CONCLUSION: Decreased serum APN levels may reflect disease severity of nontraumatic ONFH.

摘要

目的：已检测到股骨头坏死（ONFH）患者脂联素（APN）水平降低。本研究旨在探讨非创伤性ONFH患者血清APN水平与疾病严重程度之间的关系。 患者与方法：在估算样本量后，本研究纳入了92例非创伤性ONFH患者和92例健康对照。采用酶联免疫吸附测定（ELISA）检测血清APN浓度。通过Ficat分级系统确定影像学进展。通过视觉模拟量表（VAS）、Harris髋关节评分（HSS）和西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分评估临床严重程度。 结果：ONFH患者的血清APN水平显著低于健康对照。Ficat 4期ONFH患者的血清APN水平显著低于3期患者，3期患者的APN水平低于2期患者。血清APN水平与Ficat分级系统呈负相关。此外，血清APN水平也与VAS和WOMAC评分呈负相关，与HSS评分呈正相关。 结论：血清APN水平降低可能反映非创伤性ONFH的疾病严重程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/9797cf508ad5/jpr-10-2387Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/422449108dcf/jpr-10-2387Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/63ac313b9601/jpr-10-2387Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/a2454926a0af/jpr-10-2387Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/9797cf508ad5/jpr-10-2387Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/422449108dcf/jpr-10-2387Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/63ac313b9601/jpr-10-2387Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/a2454926a0af/jpr-10-2387Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f02c/5633271/9797cf508ad5/jpr-10-2387Fig4.jpg

相似文献

[1]
Attenuated serum adiponectin levels are associated with disease severity in patients with non-traumatic osteonecrosis of the femoral head.

J Pain Res. 2017-10-3

[2]
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Ann Clin Biochem. 2018-7

[3]
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[4]
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J Orthop Surg Res. 2021-5-20

[5]
Decreased serum MMP-9 levels in patients with nontraumatic osteonecrosis of the femoral head.

BMC Musculoskelet Disord. 2023-3-29

[6]
Reduced serum and local LncRNA MALAT1 expressions are linked with disease severity in patients with non-traumatic osteonecrosis of the femoral head.

Technol Health Care. 2021

[7]
Correlation of serum and local CXCL13 levels with disease severity in patients with non-traumatic osteonecrosis of femoral head.

J Orthop Surg Res. 2024-3-1

[8]
Plasma and local expressions of CircRNA CDR1as are linked with disease severity in patients with non-traumatic osteonecrosis of femoral head.

J Orthop Surg Res. 2020-12-9

[9]
Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1.

Open Med (Wars). 2024-3-30

[10]
Serum glutathione peroxidase 4 as a novel biomarker for nontraumatic osteonecrosis of the femoral head: A retrospective case-control study.

Medicine (Baltimore). 2023-12-15

引用本文的文献

[1]
Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid.

Sci Rep. 2025-8-21

[2]
Plasma lipidomics analysis reveals altered lipids signature in patients with osteonecrosis of the femoral head.

Metabolomics. 2022-2-11

本文引用的文献

[1]
Adiponectin signaling and function in insulin target tissues.

J Mol Cell Biol. 2016-4

[2]
Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver.

Curr Pathobiol Rep. 2015-12-1

[3]
Unique plasma metabolomic signature of osteonecrosis of the femoral head.

J Orthop Res. 2016-7

[4]
Current concepts on osteonecrosis of the femoral head.

World J Orthop. 2015-9-18

[5]
Adiponectin-Mediated Analgesia and Anti-Inflammatory Effects in Rat.

PLoS One. 2015-9-9

[6]
Analysis of outcome of avascular necrosis of femoral head treated by core decompression and bone grafting.

J Clin Orthop Trauma. 2015-9

[7]
Combining Concentrated Autologous Bone Marrow Stem Cells Injection With Core Decompression Improves Outcome for Patients with Early-Stage Osteonecrosis of the Femoral Head: A Comparative Study.

J Arthroplasty. 2015-9

[8]
The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases.

Biochim Biophys Acta. 2015-9

[9]
Biomarkers and pharmaceutical strategies in steroid-induced osteonecrosis of the femoral head: a literature review.

J Int Med Res. 2015-2

[10]
Combination treatment of biomechanical support and targeted intra-arterial infusion of peripheral blood stem cells mobilized by granulocyte-colony stimulating factor for the osteonecrosis of the femoral head: a randomized controlled clinical trial.

J Bone Miner Res. 2015-4

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