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紫杉醇洗脱支架与紫杉醇洗脱球囊治疗支架内再狭窄的效果分析

Analysis of the effect of paclitaxel-eluting stents and paclitaxel-eluting balloon in the treatment of in-stent restenosis.

作者信息

Cheng Jiangtao, Gao Chuanyu, Liu Yuhao, Wang Zhongmin, Zheng Xiaohui, Qi Datun

机构信息

Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan, PR China.

出版信息

Pak J Pharm Sci. 2017 Jul;30(4(Suppl.)):1521-1524.

Abstract

To compare and analyze the effect and the safety of the paclitaxel-eluting stents and paclitaxel-eluting balloon in the treatment for in-stent rest enosis. 120 cases, who had been undergone percutaneous coronary intervention (PCI) in the Department of Cardiology of Henan Provincial People's Hospital from January 2012 to January 2014 were selected. All the patients were randomly treated with paclitaxel-eluting balloon or paclitaxel-eluting stents. The former were divided into different groups that named group A and the later group B. All the selected patients signed the informed consent on interventional therapy and be given anti-platelet drugs before operating. At the same time, they had routine examination, like chest X-ray, ultrasound, biochemical detection, Myocardial injury markers. (1) The two groups had no significant difference in the general information (P>0.05); (2) The success rate in the two groups reached 100% and (3) All the patients were visited in the 9th, 12th and 24th month to see if any of them was dead. The reexamination results in the 9th month showed that both drug-eluting balloon and drug-eluting stents were safe and effective in treating coronary artery in-stent restenosis. In addition, drug-eluting balloon was more effective than drug-eluting stents to prevent from the in-stent restenosis.

摘要

比较分析紫杉醇洗脱支架和紫杉醇洗脱球囊治疗支架内再狭窄的疗效及安全性。选取2012年1月至2014年1月在河南省人民医院心内科行冠状动脉介入治疗(PCI)的120例患者。所有患者随机接受紫杉醇洗脱球囊或紫杉醇洗脱支架治疗。前者分为A组,后者分为B组。所有入选患者均签署介入治疗知情同意书,并在术前给予抗血小板药物。同时,他们进行了常规检查,如胸部X线、超声、生化检测、心肌损伤标志物检测。(1)两组一般资料无显著差异(P>0.05);(2)两组成功率均达100%;(3)所有患者在第9、12和24个月进行随访,观察是否有死亡情况。第9个月的复查结果显示,药物洗脱球囊和药物洗脱支架治疗冠状动脉支架内再狭窄均安全有效。此外,药物洗脱球囊在预防支架内再狭窄方面比药物洗脱支架更有效。

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