Guo Ying, Chang Eugene, Bozkurt Mehtap, Park Minjeong, Liu Diane, Fu Jack B
Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Medicine, Division of Physical Medicine and Rehabilitation, Toronto Rehabilitation Institute, Toronto, Canada.
J Surg Oncol. 2018 Mar;117(3):529-534. doi: 10.1002/jso.24878. Epub 2017 Oct 16.
Total pelvic exenteration are performed in patients with locally advanced or recurrent pelvic malignances. Many patients have prolong hospital length of stay (LOS), but risk factors are not clearly identified.
From 2002 through 2012, 100 consecutive patients undergoing pelvic exenteration were retrospectively reviewed. A general linear model was used to examine risk factors for prolonged hospital LOS.
Among the 100 patients, 51 had gastrointestinal cancer, 14 had genitourinary cancer, 31 had gynecologic cancer, and 4 had sarcoma. Perioperative complications included infection (n = 44), anastomotic leak/fistula (n = 6), wound or flap dehiscence (n = 11), and ileus or bowel obstruction (n = 30). The median (Interquartile range (IQR)) hospital LOS was 15 days (10-21.5 days). On multivariate regression analysis, hospital LOS was significantly prolonged by underweight status, genitourinary cancer or sarcoma diagnosis, ≥2 infections, anastomotic leak/fistula, requiring rehabilitation consult and admission, and ≥2 consultations (P = 0.05).
In patients undergoing pelvic exenteration, prolonged hospital LOS is associated with underweight status, genitourinary cancer or sarcoma diagnosis, more than one infection, anastomotic leak/fistula, requiring rehabilitation consult and admission, and more than one consultation. Further study is needed to assess whether minimizing these risk factors can improve hospital LOS in these patients.
全盆腔脏器切除术用于治疗局部晚期或复发性盆腔恶性肿瘤患者。许多患者住院时间延长,但风险因素尚不明确。
回顾性分析2002年至2012年连续接受盆腔脏器切除术的100例患者。采用一般线性模型检查住院时间延长的风险因素。
100例患者中,51例患有胃肠道癌,14例患有泌尿生殖系统癌,31例患有妇科癌,4例患有肉瘤。围手术期并发症包括感染(n = 44)、吻合口漏/瘘(n = 6)、伤口或皮瓣裂开(n = 11)以及肠梗阻(n = 30)。中位(四分位间距(IQR))住院时间为15天(10 - 21.5天)。多因素回归分析显示,体重过轻、泌尿生殖系统癌或肉瘤诊断、≥2次感染、吻合口漏/瘘、需要康复咨询及住院以及≥2次咨询会显著延长住院时间(P = 0.05)。
在接受盆腔脏器切除术的患者中,住院时间延长与体重过轻、泌尿生殖系统癌或肉瘤诊断、不止一次感染、吻合口漏/瘘、需要康复咨询及住院以及不止一次咨询有关。需要进一步研究以评估降低这些风险因素是否能改善这些患者的住院时间。