Ikejiri Makoto, Wada Hideo, Tone Shine, Wakabayashi Hiroki, Hasegawa Masahiro, Matsumoto Takeshi, Fujimoto Naoki, Yamada Norikazu, Ito Masaaki, Nakatani Kaname, Sudo Akihiro
Department of Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan.
Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan.
Thromb J. 2017 Oct 12;15:27. doi: 10.1186/s12959-017-0150-4. eCollection 2017.
Measurement of edoxaban plasma concentration has been gathering attention in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE).
The anti-Xa activity was measured one hour after edoxaban intake using 3 different assays in 200 patients after major orthopedic surgery.
The anti-Xa activities on Day 8 were significantly higher than those on Day 4 and those on Day 4 were significantly higher than those on Day 1. The anti-Xa activities in two assays closely correlated with each other, but the other anti-Xa assay did not correlated with other two assays. The anti-Xa activities as detected in the three Xa assays were significantly higher in the patients without deep vein thrombosis (DVT) than in those with DVT on Day 4. Additionally, there were no significant differences in the anti-Xa activities of assays A, B and C between patients with and without massive bleeding (MB) on Days 1, 4, 8 and 15.
The results of this study suggest that anti-Xa level could be predictive of the risk of VTE, but not of the risk of massive bleeding.
在接受依度沙班预防静脉血栓栓塞（VTE）的主要骨科手术患者中，依度沙班血浆浓度的测量一直备受关注。
在200例主要骨科手术后的患者中，使用3种不同的检测方法在依度沙班摄入1小时后测量抗Xa活性。
第8天的抗Xa活性显著高于第4天，第4天的抗Xa活性显著高于第1天。两种检测方法中的抗Xa活性彼此密切相关，但另一种抗Xa检测方法与其他两种检测方法不相关。在第4天，三种Xa检测方法中检测到的抗Xa活性在无深静脉血栓形成（DVT）的患者中显著高于有DVT的患者。此外，在第1、4、8和15天，有大出血（MB）和无大出血的患者在检测方法A、B和C的抗Xa活性方面没有显著差异。
本研究结果表明，抗Xa水平可预测VTE风险，但不能预测大出血风险。
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