低危转移性妊娠滋养细胞肿瘤五天化疗期间的血清甲氨蝶呤和人绒毛膜促性腺激素浓度
Serum methotrexate and human chorionic gonadotropin concentrations during five-day chemotherapy for low-risk metastatic gestational trophoblastic neoplasia.
作者信息
Hilgers R D, Standefer J C, Bowling M C, Greeley P
机构信息
Department of Obstetrics and Gynecology, University of New Mexico Medical Center, Albuquerque.
出版信息
Int J Gynaecol Obstet. 1988 Dec;27(3):421-5. doi: 10.1016/0020-7292(88)90124-5.
A recent report of serum methotrexate (MTX) levels measured during treatment of gestational trophoblastic neoplasia (GTN) led us to determine MTX and human chorionic gonadotropin (beta-hCG) levels in a patient with low-risk metastatic GTN with a pulmonary metastasis. Peak MTX concentrations exceeded 10(-6) mol/l considered by many investigators to be within the therapeutic range against many human tumors. Serum beta-hCG levels did not decline during MTX administration; however, after 5 days of MTX a steep dose-response curve was observed which continued during 5 courses of chemotherapy.
最近一份关于妊娠滋养细胞肿瘤（GTN）治疗期间血清甲氨蝶呤（MTX）水平的报告促使我们测定了一名患有低风险转移性GTN且伴有肺转移患者的MTX和人绒毛膜促性腺激素（β-hCG）水平。MTX峰值浓度超过了许多研究者认为对多种人类肿瘤具有治疗作用的10^(-6) mol/L。在给予MTX期间血清β-hCG水平并未下降；然而，在MTX治疗5天后观察到一条陡峭的剂量反应曲线，该曲线在5个化疗疗程中持续存在。
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